摘要
目的观察甲钴胺联合谷胱甘肽对卵巢癌患者紫杉醇化疗所致外周神经毒性的预防作用。方法选取2015年6月~2018年6月我院收治的使用紫杉醇化疗的卵巢癌患者共106例,随机分为观察组53例和对照组53例。两组患者均给予TC方案(紫杉醇+卡铂)化疗,对照组给予甲钴胺预防神经毒性。观察组给予甲钴胺联合谷胱甘肽预防神经毒性。在治疗3周期后、治疗6周期后、化疗结束6个月后,分别对两组的外周神经毒性进行评价。化疗期间,密切观察并记录两组患者出现外周神经毒性症状的时间及出现外周神经毒性症状时紫杉醇使用量。比较两组患者化疗前后一般生活状况评分(KPS评分)。结果治疗3周期后、治疗6周期后及化疗结束6个月后,观察组外周神经毒性发生率分别为37.74%、47.17%、33.96%,均明显低于对照组(P<0.05)。治疗期间,观察组患者出现外周神经毒性的时间为(15.25±1.78)周,晚于对照组的(10.32±1.51)周(P<0.05),紫杉醇使用量为(431.78±42.32)mg/m^2明显大于对照组的(327.12±31.71)mg/m^2(P<0.05)。治疗后,观察组的KPS评分(75.33±7.42)分高于对照组的(70.36±7.62)分(P<0.05)。结论甲钴胺联合谷胱甘肽能有效预防紫杉醇所致卵巢癌患者外周神经毒性,值得临床参考并进一步推广应用。
Objective To observe the preventive effect of mecobalamin combined with glutathione on peripheral neurotoxicity induced by paclitaxel chemotherapy in patients with ovarian cancer.Methods A total of 106 patients with ovarian cancer who were admitted and treated with paclitaxel chemotherapy in our hospital from June 2015 to June 2018 were selected and randomly divided into the observation group(53 cases)and the control group(53 cases).Both groups of patients were given TC regimen(paclitaxel+carboplatin)for chemotherapy.The control group was given mecobalamin to prevent neurotoxicity.The observation group was given mecobalamin combined with glutathione to prevent neurotoxicity.After 3 cycles of treatment,6 cycles of treatment,and 6 months after the end of chemotherapy,the peripheral neurotoxicity of the two groups were evaluated.During chemotherapy,the onset time of peripheral neurotoxicity symptoms and the dosage of paclitaxel at the onset of peripheral neurotoxicity symptoms were closely observed and recorded.The general living condition score(KPS score)before and after chemotherapy was compared between the two groups.Results After 3 cycles of treatment,6 cycles of treatment,and 6 months after the end of chemotherapy,the incidence rate of peripheral neurotoxicity in the observation group was 37.74%,47.17%and 33.96%respectively,which were significantly lower than those in the control group(P<0.05).During treatment,the time of peripheral neurotoxicity in the observation group was(15.25±1.78)weeks was later than that in the control group of(10.32±1.51)weeks(P<0.05).The dosage of paclitaxel was(431.78±42.32)mg/m^2 was significantly greater than that in the control group(327.12±31.71)mg/m^2(P<0.05).After treatment,the KPS score in the observation group of(75.33±7.42)points was higher than that in the control group(70.36±7.62)points(P<0.05).Conclusion Mecobalamin combined with glutathione can effectively prevent paclitaxel-induced peripheral neurotoxicity in the patients with ovarian cancer,which is worthy of clin
作者
钟丽萍
潘月芬
沈俊俊
齐全
廖海红
姜亦珍
韩书文
ZHONG Liping;PAN Yuefen;SHEN Junjun;QI Quan;LIAO Haihong;JIANG Yizhen;HAN Shuwen(Department of Medical Oncology,Huzhou Central Hospital in Zhejiang Province,the Affiliated Central Hospital Huzhou University in Zhejiang Province,Huzhou313000,China)
出处
《中国现代医生》
2020年第28期117-120,共4页
China Modern Doctor
基金
浙江省医药卫生科技计划项目(2019RC285)。
关键词
甲钴胺
谷胱甘肽
卵巢癌
紫杉醇
外周神经毒性
Mecobalamin
Glutathione
Ovary cancer
Paclitaxel
Peripheral neurotoxicity
