摘要
慢性阻塞性肺疾病(COPD)作为一种慢性肺部疾病被人们熟知。近年来,随着对其认识的加深,COPD的各种并发症,尤其是肺动脉高压(PH)得到越来越多的关注。COPD合并PH患者的病死率升高且预后较差,严重影响了患者的生活质量,且对该疾病的治疗尚缺乏疗效确切的药物。为了充分了解该疾病的治疗现状,就COPD合并PH的药物治疗的研究进展进行综述。结果显示,对于COPD合并PH患者,应该对其基础疾病进行最佳治疗,而使用他汀类药物及法舒地尔可能是有益的,但靶向药物的效果仍存在较大争议。未来需要开展更多大型随机对照试验进一步明确各类药物对COPD的疗效。
Chronic obstructive pulmonary disease(COPD)is well known as a chronic lung disease.In recent years,with the deepening of its understanding,various complications of COPD,especially pulmonary hypertension(PH)have received more and more attention.COPD patients with PH have an increased fatality rate and a poor prognosis,which seriously affects the quality of life of the patients,and the treatment of the disease lacks effective drugs.In order to fully understand the current status of the treatment of the disease,the research progress of the drug treatment of COPD combined with PH was reviewed.The results show that for patients with COPD and PH,the best treatment should be given to their underlying diseases.The use of statins and fasudil may be beneficial,but the effect of targeted drugs is still controversial.In the future,more large randomized controlled trials need to be carried out to further clarify the efficacy of various drugs on COPD.
作者
高蓓蓓
李晓芳
毛毅敏
Gao Beibei;Li Xiaofang;Mao Yimin(Clinical Medical College of Henan University of Science and Technology,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471003,China;Department of Respiratory and Critical Care Medicine,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471003,China)
出处
《国际生物医学工程杂志》
CAS
2020年第4期335-339,共5页
International Journal of Biomedical Engineering
关键词
慢性阻塞性肺疾病
肺动脉高压
药物
治疗
Chronic obstructive pulmonary disease
Pulmonary hypertension
Drugs
Treatment
