摘要
目的回顾性分析52例新型冠状病毒肺炎(COVID-19)患者的临床资料,探讨加用中医“三焦次第疗法”方药后的中西医结合治疗COVID-19的临床疗效。方法收集自2020年1月30日—2020年3月5日在广西壮族自治区人民医院、南宁市第四人民医院等8家医院52例COVID-19患者的临床资料,按照治疗方法不同分为西药对照组(21例)和中西药治疗组(31例),西药组给予西药抗病毒、抗感染、对症支持治疗,中西药组在西药组治疗基础上根据COVID-19分型给予基于“三焦次第疗法”的三首中药复方汤剂治疗,比较两组患者治疗前后的中医证候积分、实验室检查、体温复常时间及核酸转阴时间、CT影像好转情况、平均住院天数、临床治愈率及病死率等。结果①两组治疗后中医证候量表积分较治疗前均明显降低(P<0.01),观察组较对照组降低更为明显(P<0.05)。且治疗组体温复常时间及平均住院天数较对照组明显缩短(P<0.05)。②两组治疗前的实验室检查异常结果显示LYMPH%明显减少,AST和ALT、D-Dimer轻微增高,CRP和ESR明显升高。经治疗后,两组LYMPH%、AST和ALT、D-Dimer均恢复到正常水平,CRP水平明显下降(P<0.05);观察组CRP和ESR水平下降较对照组更为明显(P<0.05);观察组较对照组核酸转阴平均时间更短(P<0.05)。③观察组临床治愈率及CT影像好转率均明显高于对照组(P<0.05);而普通型转重型发生率明显低于对照组(P<0.05),且观察组无死亡病例,无明显不良反应。结论加用“三焦次第疗法”的中西医结合治疗COVID-19能显著改善患者的实验室及影像学检测异常指标和临床症状,缩短病程,提高临床治愈率,且优于单纯西药治疗组。
Objective To observe the clinical efficacy of combined treatment of traditional Chinese(Triple-Jiao Sequential Therapy) and western medicine through retrospective analysis of the clinical data of 52 patients with corona virus disease 2019(COVID-19). Method Fifty-two patients with COVID-19 from 8 hospitals including People’s Hospital of Guangxi Zhuang Autonomous Region, The Fourth People’s Hospital of Nanning and other hospitals were collected from January 30, 2020 to March 5, 2020. According to different intervention methods, patients were divided into Western medicine control group(21 cases) and TCM combined with Western medicine treatment group(31 cases). The control group was given Western medicine antiviral, anti-infection and symptomatic support treatments. The TCM combined with Western medicine treatment group used Chinese herbal compound based on the "Triple-Jiao Sequential Therapy" according to classification of COVID-19. And then we compared the TCM syndrome scores, laboratory test results,the time of body temperature returned to normal and viral nucleic acid turned negative,CT image improvement, average hospitalization days, clinical cure rate and mortality and others between the two groups before and after treatment. Results(1)After treatment, the scores of the TCM syndrome scale of both groups were significantly lower(P<0.01), and the score of the observation group was more significantly reduced than that of the control group(P<0.05). In addition, the time of body temperature returned to normal and average hospitalization days in the treatment group were significantly shorter than those in the control group(P<0.05).(2)The laboratory tests before treatment in the two groups showed that LYMPH% decreased significantly, levels of AST,ALT and D-Dimer increased slightly, and levels of CRP and ESR increased significantly. After treatment, LYMPH%, levels of AST, ALT and D-Dimer in both groups returned to be normal, and CRP level decreased significantly(P<0.05). The levels of CRP and ESR in the observation
作者
胡跃强
卢健棋
黄进
黄秋华
金海浩
马钰婷
杨焕彪
莫柳芬
唐农
HU Yueqiang;LU Jianqi;HUANG Jin;HUANG Qiuhua;JIN Haihao;MA Yuting;YANG Huanbiao;MO Liufen;TANG Nong(The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023,Guangxi,China;People’s Hospital of Guangxi Zhuang Autonomous Region,Nanning 530022,Guangxi,China;Liuzhou People’s Hospital,Liuzhou 545006,Guangxi,China;The Fourth People’s Hospital of Nanning,Nanning 530023,Guangxi,China;Yulin Red Cross Hospital,Yulin 537000,Guangxi,China;Beihai Hospital of Traditional Chinese Medicine,Beihai 536000,Guangxi,China;Guangxi University of Traditional Chinese Medicine,Nanning 530001,Guangxi,China)
出处
《中华中医药学刊》
CAS
北大核心
2020年第10期1-5,共5页
Chinese Archives of Traditional Chinese Medicine
基金
国家中医药管理局新冠肺炎中医药应急专项(2020ZYLCYZ05-9)
广西科技厅新冠肺炎应急科技专项(2020AB39020)
广西中医药管理局新冠肺炎应急专项(GXZYYJ2020-1)。
关键词
新型冠状病毒肺炎
三焦次第疗法
回顾性分析
临床疗效
COVID-19
Triple-Jiao Sequential Therapy
retrospective analysis
clinical curative effect
