摘要
泛素化是泛素通过多级酶联反应与底物蛋白共价结合的过程。当易于聚集的泛素化蛋白质堆积而不被及时清理掉时,会威胁细胞的健康和生存能力。然而,一些关键蛋白质的泛素化降解却能导致相关疾病的发生。本文总结了有关泛素化蛋白质的降解机制在眼科疾病发生发展过程中的研究进展,以期为临床诊疗提供新思路、新策略。
Ubiquitination is the process by which ubiquitin is covalently attached to substrate proteins through multistage enzymatic reactions.When the aggregated ubiquitinated proteins are overloaded and cannot be cleaned up in time,the health and viability of cells will be threatened.However,the ubiquitination and degradation of some key proteins may cause related diseases.In this review,we summarize the research progress on the degradation mechanisms of ubiquitinated proteins in ophthalmic diseases,in order to provide new ideas and strategies for clinical diagnosis and treatment.
作者
陈晓娟
张国伟
秦苗苗
管怀进
Chen Xiaojuan;Zhang Guowei;Qin Miaomiao;Guan Huaijin(Department of Ophthalmology,the Affiliated Hospital of Nantong University,Nantong 226000,China)
出处
《国际眼科纵览》
2020年第5期366-372,共7页
International Review of Ophthalmology
基金
国家自然科学基金(81974129)。
关键词
泛素化
降解
眼科疾病
ubiquitination
degradation
ophthalmic diseases
