摘要
在犯罪现场侦查过程中,正确识别现场留下的生物斑迹组织来源非常重要。非编码RNA(non-coding RNA,ncRNA)是指转录组中不翻译为蛋白质的RNA分子,它在诸多体液(外周血、月经血、精液、唾液、阴道分泌物等)中皆有丰富的特异性表达,因而具备体液组织来源鉴定的潜力。由于其具备特殊结构,诸多ncRNA标记物展现出较好的灵敏度、特异度及稳定性,具有一定的检验优势。本文对非编码RNA在体液斑迹鉴定中的应用及其前景进行综述。
To correctly identify the origin of body fluids left on the scene is an important part of forensic casework.Non-coding RNA(nc RNA),a series of RNA molecule which wouldn’t be translated into proteins,has abundant specific expression in many body fluids(peripheral blood,menstrual blood,semen,saliva,vaginal secretions,etc.).so it has the potential to identify the source of body fluids Due to their special structures,numerous ncRNA markers show considerable value of examination in sensitivity,specificity and stability.This article reviews the application and prospects of non-coding RNA in body fluids identification.
作者
张琦
赵禾苗
李永久
陈静
畅晶晶
杨瑞琴
王冲
Zhang Qi;Zhao Hemiao;Li Yongjiu;Chen Jing;Chang Jingjing;Yang Ruiqin;Wang Chong(People's Public Security University of China,Beijing 100038,China;Key Laboratory of Forensic Genetics,Institute of Forensic Science,Ministry of Public Security,Beijing 100038,China)
出处
《中国法医学杂志》
CSCD
2020年第5期514-517,共4页
Chinese Journal of Forensic Medicine
基金
中共级公益性科研院所基本科研业务费专项项目(2018JB012)。
