摘要
股骨头坏死(osteonecrosis of the femoral head,ONFH)是临床上最常见的骨关节疾病之一,由于发病机制尚未明确,所以目前暂无疗效确切的药物治疗方案。随着祖国医学对ONFH研究的不断深入,发现淫羊藿苷(Icariin,ICA)可通过经典Wnt/β-catenin、RANK/RANKL、Notch、PI3K/AKT及MAPK信号通路调节骨代谢平衡以增强骨密度及强度,同时可促进微血管修复以改善股骨头局部血供,从而达到治疗ONFH的最终效果。本文就ICA防治ONFH的具体分子作用机制进行综述,旨为今后临床运用ICA治疗ONFH提供一定的参考。
Osteonecrosis of the femoral head(ONFH)is one of the most common bone and joint diseases in clinic.Because the pathogenesis is not clear,there is no effective drug treatment plan at present.With the deepening of research on ONFH in traditional Chinese medicine,it has been found that icariin(ICA)regulates the balance of bone metabolism and promotes the repair of microvasculature through Wnt/β-catenin,RANK/RANKL,Notch,PI3K/Akt,and MAPK pathways.ICA has significant effect on improving the blood supply of femoral head area and promoting the repair of osteonecrosis.In this paper,the specific molecular mechanism of ICA in the prevention and treatment of ONFH is reviewed,in order to provide reference for the clinical application of ICA in the treatment of ONFH in the future.
作者
章晓云
李华南
陈跃平
ZHANG Xiaoyun;LI Hua′nan;CHEN Yueping(Jiangxi University of Traditional Chinese Medicine, Nanchang 330004;Department of Orthopedics, Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese Medicine, Nanning 530011;Department of Orthopedics and Traumatology, the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China)
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2020年第11期1694-1699,共6页
Chinese Journal of Osteoporosis
基金
国家自然科学基金(81760796,81960803)
广西自然科学基金青年基金(2020GXNSFBA159053)
广西高校青年教师基础能力提升项目(2019KY0352)
广西中医药大学2019年校级科研课题(2019QN027)
广西中医药大学一流学科课题(2019XK029)
2016年全国名老中医传承工作室建设项目(桂卫中医发{2016}11号)
广西中医药大学岐黄工程培育项目(2018004)。
关键词
淫羊藿苷
股骨头坏死
分子机制
信号通路
icariin
necrosis of femoral head
molecular mechanism
signaling pathway
