摘要
随着肿瘤心脏病这一新兴学科的发展,人们对化疗引起的心脏毒性及相关机制逐渐重视。吉西他滨作为阿糖胞苷的类似物,在肿瘤治疗中常需大剂量持续静脉给药,在部分患者中可能引起一系列不良反应包括心脏毒性。吉西他滨引起的心脏毒性主要表现为心律失常、心力衰竭和心肌梗死,机制涉及炎症-纤维化、电生理紊乱和信号通路的改变等。现参考国内外文献,对吉西他滨引起心脏毒性的临床表现及相关机制进行阐述,以期为临床实践提供新思路。
With the development of cardio-oncology,more and more attention has been paid to the cardiac toxicity and related mechanisms caused by chemotherapy.Gemcitabine,an analogue of cytarabine,is used via large doses of continuous intravenous administration in treatment of cancer,which may lead to side effects including cardiotoxicity in some patients.Cardiotoxicity induced by gemcitabine could be manifested as arrhythmia,heart failure and myocardial infarction,and the mechanisms involve inflammation,fibrosis,electrophysiological disorder,signal pathway changes,etc.In this paper,we reviewed the clinical manifestations and related mechanisms of cardiotoxicity induced by gemcitabine in order to provide new ideas for clinical practice.
作者
唐雨琦
关旭敏
方凤奇
刘基巍
夏云龙
TANG Yuqi;GUAN Xumin;FANG Fengqi;LIU Jiwei;XIA Yunlong(Department of Cardiology,The First Affiliated Hospital of Dalian Medical University,Dalian 116000,Liaoning,China)
出处
《心血管病学进展》
CAS
2020年第9期895-899,共5页
Advances in Cardiovascular Diseases
