摘要
目的探讨枸橼酸咖啡因注射液治疗呼吸暂停患儿的临床疗效及安全性。方法选取2019年2月至2020年4月遵义市妇幼保健院收治的86例呼吸暂停的患儿(均为早产儿)作为本次研究对象,以随机数字表法将其分为对照组与试验组,每组43例。对照组患儿采用氨茶碱进行治疗,试验组采用枸橼酸咖啡因注射液治疗。比较两组患儿呼吸暂停情况(呼吸暂停持续时间、呼吸暂停次数、症状消退时间),治疗总有效率,治疗前后的智力发育指数(MDI)评分、运动发育指数(PDI)评分及不良反应发生情况。结果试验组患儿治疗总有效率明显高于对照组(97.67%vs.76.74%),呼吸暂停持续时间、呼吸暂停次数及症状消退时间均明显少于对照组,差异均有统计学意义(P<0.05)。治疗前,两组患儿MDI、PDI评分比较,差异无统计学意义(P>0.05);治疗后,试验组MDI、PDI评分显著高于对照组,差异有统计学意义(P<0.05)。试验组患儿不良反应发生率明显低于对照组,差异有统计学意义(P<0.05)。结论枸橼酸咖啡因注射液治疗呼吸暂停患儿的临床效果显著,可显著改善患儿的临床症状,提高患儿临床治疗总有效率,降低其不良反应的发生,安全性较高。
Objective To explore the clinical effect and safety of caffeine citrate injection in the treatment of children with apnea.Methods A total of 86 children with apnea(all preterm infants)admitted to Zunyi Maternal and Child Health Hospital from February 2019 to April 2020 were randomly selected as the subjects in this study.They were divided into a control group and an experimental group,43 cases in each group.Children in the control group were treated with aminophylline,while those in the experimental group were treated with caffeine citrate injection.The situation of apnea(duration of apnea,frequency of apnea,time of symptom disappearance),total effective rate of treatment,scores of mental development index(MDI)and motor development index(PDI)before and after treatment,and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the experimental group was significantly higher than that in the control group(97.67%vs.76.74%),the duration of apnea,the frequency of apnea and the time of symptom disappearance were significantly lower than those in the control group,and the differences were all statistically significant(P<0.05).Before treatment,there was no statistically significant difference in MDI and PDI scores between the two groups(P>0.05).After treatment,MDI and PDI scores of the experimental group were significantly higher than those of the control group,with statistically significant differences(P<0.05).The incidence of adverse reactions in the experimental group was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The clinical effect of caffeine citrate injection in the treatment of children with apnea is significant.It can significantly improve the clinical symptoms of children,improve the total effective rate of clinical treatment of children,reduce the incidence of adverse reactions,with a high safety.
作者
谢颖
刘世龙
杨雯
XIE Ying;LIU Shilong;YANG Wen(Zunyi Maternal and Child Health Hospital,Zunyi,Guizhou 563000,China)
出处
《大医生》
2020年第12期88-90,共3页
Doctor
