摘要
目的探讨高血压患者肾功能相关指标与血压变异性(BPV)和细胞因子水平的关系。方法选取2016年3月至2018年4月在该院接受治疗的高血压患者80例,根据其是否并发肾功能损伤分为肾损伤组(n=25)和非肾损伤组(n=55),并选取同期在该院体检的健康成年人80例作为对照组。观察3组对象血清肌酐(SCr)、血尿素氮(BUN)、BPV和细胞因子水平,分析高血压患者SCr、BUN与BPV和细胞因子水平的相关性。结果SCr、BUN、尿微量清蛋白与肌酐比值(ACR)水平由高到低分别为肾损伤组[(87.69±4.31)μmol/L、(8.19±1.27)mmol/L、32.05±4.98]、非肾损伤组[(63.18±3.97)μmol/L、(6.25±1.13)mmol/L、24.13±3.45]和对照组[(55.02±5.28)μmol/L、(4.03±1.01)mmol/L、5.36±1.02],3组对象比较差异有统计学意义(F=15.052、20.174、18.794,P<0.05);高敏C反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α)、胱抑素-C(CysC)水平由高到低分别为肾损伤组[(12.53±2.06)mg/L、(25.64±2.02)ng/L、(1.35±0.32)mg/L]、非肾损伤组[(8.29±1.32)mg/L、(17.81±3.06)ng/L、(0.98±0.21)mg/L]和对照组[(4.36±1.18)mg/L、(10.92±2.23)ng/L、(0.58±0.14)mg/L],3组对象比较差异有统计学意义(F=18.264、20.157、16.495,P<0.01);24 h收缩压标准差(24 hSBPSD)、24 h舒张压标准差(24 hDBPSD)、24 h收缩压变异性(24 hSBPV)、24 h舒张压变异性(24 hDBPV)水平由高到低分别为肾损伤组、非肾损伤组和对照组,3组对象比较差异有统计学意义(F=22.365、18.278、16.127、15.493,P<0.001);Pearson相关分析显示,高血压患者的SCr、BUN、ACR水平与BPV和细胞因子水平均明显正相关。结论高血压患者血清SCr、BUN水平较高,且与BPV和细胞因子水平有密切联系。
Objective To investigate the relationship between the renal function related indexes with the blood pressure variability(BPV)and cytokine levels in the patients with hypertension.Methods Eighty patients with hypertension treated in this hospital from March 2016 to April 2018 were selected and divided into the renal injury group(n=25)and non-renal injury group according to whether complicating renal function impairment.Eighty healthy adults undergoing the physical examination in this hospital at the same period served as the control group.The levels of serum SCr,BUN,BPV and cytokine levels were observed in the three groups,and the correlation between SCr and BUN with BPV and cytokine levels in the patients with hypertension was analyzed.Results The levels of SCr,BUN,and urinary microalbumin to creatinine ratio(ACR)from high to low were the renal injury group[(87.69±4.31)μmol/L,(8.19±1.27)mmol/L,(32.05±4.98)mg/mol],non-renal injury group[(63.183.97)μmol/L,(6.25±1.13)mmol/L,(24.13±3.45)mg/mol]and control group[(55.02±5.28)μmol/L,(4.03±1.01)mmol/L,(5.36±1.02)mg/mol],and the differences among 3 groups were statistically significant(F=15.052,20.174,18.794,P<0.05);the levels of hs-CRP,TNF-α,and CysC from high to low were the renal injury group[(12.53±2.06)mg/L,(25.64±2.02))ng/L,(1.35±0.32)mg/L],non-renal injury group[(8.29±1.32)mg/L,(17.81±3.06)ng/L,(0.98±0.21)mg/L]and control group[(4.36±1.18)mg/L,(10.92±2.23)ng/L,(0.58±0.14)mg/L],and the differences were statistically significant(F=18.264,20.157,16.495,P<0.01);the levels of 24 hSBPSD,24 hDBPSD,24 hSBPV,and 24 hDBPV from high to low were the complicating renal injury group[(14.26±2.08)mm Hg,(8.85±1.12)mm Hg,(12.47±2.05)mm Hg,(8.46±1.03)mm Hg],non-renal injury group[(10.27±2.15)mm Hg,(6.98±1.01)mm Hg,(9.28±1.32)mm Hg,(6.01±1.24)mm Hg]and the control group[(8.15±1.72)mm Hg,(5.21±0.98)mm Hg,(6.47±1.01)mm Hg,(4.35±0.92)mm Hg],and the differences were statistically significant(F=22.365,18.278,16.127,15.493,P<0.001);the Pearson correlation an
作者
韩莹
贾慧慧
赵哲
杨秀健
张晓玲
HAN Ying;JIA Huihui;ZHAO Zhe;YANG Xiujian;ZHANG Xiaoling(Department of Clinical Laboratory,Port Hospital,Hebei Port Group Co.,Ltd.,Qinhuangdao,Hebei 066000,China)
出处
《重庆医学》
CAS
2020年第21期3643-3646,共4页
Chongqing medicine
关键词
高血压
血清肌酐
血尿素氮
细胞因子类
血压变异性
hypertension
serum creatinine
blood urea nitrogen
cytokines
blood pressure variability
