摘要
目的观察硝苯地平辅助治疗对妊娠高血压患者凝血酶与心功能的影响。方法方便选取该院2017年5月—2019年9月收治的112例妊娠期高血压患者随机分为参照组与联合组,各56例,给予参照组拉贝洛尔治疗,联合组在拉贝洛尔的基础上加用硝苯地平治疗。比较治疗前后两组凝血酶指标[凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、纤维蛋白原(FIB)]、心功能指标[血清肌钙蛋白(cTnT)、血浆脑钠肽(BNP)]水平变化。结果治疗前,两组上述指标水平差异无统计学意义(P>0.05);治疗后,两组PT、APTT水平均显著升高,联合组[PT(12.36±0.56)s、APPT(28.02±1.14)s]显著高于参照组[PT(11.53±0.51)s、APTT(26.33±1.25)s],差异有统计学意义(t=8.200、7.475,P<0.05);两组FIB、cTnT、BNP水平均较治疗前显著下降,联合组[FIB(3.05±0.21)g/L、cTnT(0.006±0.002)ng/mL、BNP(183.24±23.47)pg/mL]显著低于参照组[FIB(3.92±0.25)s、cTnT(0.007±0.003)ng/mL、BNP(235.21±25.14)pg/mL],差异有统计学意义(t=19.940、2.076、11.308,P<0.05)。结论硝苯地平辅助治疗对妊娠高血患者凝血功能与心功能改善效果显著,有一定临床运用价值。
Objective To observe the effects of adjuvant nifedipine treatment on thrombin and heart function in patients with pregnancy-induced hypertension.Methods 112 patients with hypertension during pregnancy admitted to the hospital from May 2017 to September 2019 were randomly divided into a reference group and a combination group,56 cases in each group.The reference group was treated with labetalol,and the combination group was in Labbe Nifedipine was added to Lolol.Compare the two groups of thrombin indexes before and after treatment[prothrombin time(PT),activated partial prothrombin time(APTT),fibrinogen(Fib)],cardiac function indexes[serum troponin(cTnT),plasma brain sodium Peptide(BNP)]level changes.Results Before treatment,there was no statistically significant difference in the above index levels between the two groups(P>0.05).After treatment,the PT and APTT levels of the two groups increased significantly,the combination group[PT(12.36±0.56)s,APTT(28.02±1.14)s]was significantly higher than the reference group[PT(11.53±0.51)s,APTT(26.33±1.25)s],the difference was statistically significant(t=8.200,7.475,P<0.05);two groups of FIB,cTnT,BNP levels were significantly lower than before treatment,the combination group[FIB(3.05±0.21)g/L,cTnT(0.006±0.002)ng/mL,BNP(183.24±23.47)pg/mL]was significantly lower than the reference group[FIB(3.92±0.25)s,cTnT(0.007±0.003)ng/mL,BNP(235.21±25.14)pg/mL],the difference was statistically significant(t=19.940,2.076,11.308,P<0.05).Conclusion Adjuvant treatment of nifedipine has a significant effect on improving coagulation function and heart function in patients with hyperemia in pregnancy,and has certain clinical application value.
作者
汤晓芬
TANG Xiao-fen(Department of Obstetrics,Jiangsu Shengze Hospital,Suzhou,Jiangsu Province,215228 China)
出处
《中外医疗》
2020年第29期94-96,共3页
China & Foreign Medical Treatment
关键词
硝苯地平
妊娠期高血压
凝血酶
心功能
Nifedipine
Hypertension during pregnancy
Thrombin
Heart function
