摘要
目的寻找适合肾动脉粥样硬化性肾动脉狭窄(ARAS)早期筛查的实验室指标。方法选取2015年1月至2020年6月航天中心医院血管介入外科及心血管内科住院初治的ARAS患者38例为实验组,肾动脉粥样硬化性非肾动脉狭窄患者44例为对照组。回顾性分析上述患者入院时的一般临床资料、肾动脉造影或其他影像学检查结果,收集血、尿常规,凝血功能、肝肾功能、血糖、血脂、心肌损伤标志物、同型半胱氨酸(Hcy)、糖化血红蛋白(GHb)、C-反应蛋白、肾早期损伤标志物等实验室检查结果。分析两组之间有统计学差异的指标,探讨它们对ARAS早期筛查的作用。结果实验组患者男性比例、吸烟、饮酒比例,高脂血症患病率较对照组均显著增高(P<0.05),实验组血清Hcy、白蛋白、γ谷氨酰转肽酶(GGT)水平较对照组明显升高(P<0.05)。多因素Logistic回归分析,血清Hcy、白蛋白是ARAS的独立危险因素,血清Hcy对ARAS早期筛查的效率优于血清白蛋白,当Hcy>12.95μmol/L时,对ARAS诊断的灵敏度为78.9%,特异性为71.4%。结论血清Hcy检测具有简便、快速、经济的优点,可以作为ARAS早期筛查的实验室指标。
Objective To develop suitable laboratory indexes for the early screening of atherosclerotic renal artery stenosis(ARAS).Methods Thirty-eight patients with ARAS who were initially hospitalized in the Department of Vascular Interventional Surgery and Cardiovascular Medicine from January,2015 to June,2020 were selected as the experimental group,and 44 patients with atherosclerotic non-renal artery stenosis were selected as the control group.We retrospectively analyzed the general clinical data,renal arteriography and other imaging findings of these patients on admission.We also collected laboratory test results of blood and urine routine,coagulation function,liver and kidney function,blood glucose,blood lipids,myocardial injury markers,Hcy,GHb,C-reaction protein and early kidney damage markers.With these data,we evaluated the statistical differences between the two groups to explore their roles in the early screening of ARAS.Results The proportion of males,smoking and drinking,and the prevalence of hyperlipidemia in the experimental group were significantly higher than those in the control group(P<0.05).The levels of serum Hcy,albumin,and GGT in the experimental group were significantly higher than those in the control group(P<0.05).Multiple regression analysis showed that serum Hcy and albumin were independent risk factors for ARAS.The early screening efficiency of serum Hcy for ARAS was better than that of serum albumin.When Hcy>12.95μmol/L,the sensitivity for ARAS diagnosis was 78.9%,and the specificity was 71.4%.Conclusion Serum Hcy testing has the advantages of simplicity,rapidness,and being cost effective,and can be used as a laboratory indicator for the early screening of ARAS.
作者
李秀锋
杨乃宁
梁国威
张曼
LI Xiufeng;YANG Naining;LIANG Guowei;ZHANG Man(Department of Clinical Laboratory,Peking University Ninth School of Clinical Medicine,Department of Clinical Laboratory,Beijing Shijitan Hospital,Capital Medical University,Beijing 100038,China;Department of Clinical Laboratory,Aerospace Center Hospital,Beijing 100049,China;Department of Nephrology,Aerospace Center Hospital,Beijing 100049,China)
出处
《标记免疫分析与临床》
CAS
2020年第10期1715-1718,共4页
Labeled Immunoassays and Clinical Medicine
基金
尿液细胞分子诊断北京市重点实验室建设经费(编号:2020-JS02)。
