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布托啡诺预防罗库溴铵注射痛的量效关系

Dose-Response Relationship of Butorphinol in Preventing Rocuronium Induced Injection Pain
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摘要 目的探究布托啡诺预防罗库溴铵注射痛的量效关系。方法选择全身麻醉下行择期手术的患者36例,ASAⅠ~Ⅱ级,静脉给予各患者布托啡诺预处理,初始剂量设为30μg·kg-1,采用Dixon改良序贯法,依据上一患者罗库溴铵注射痛发生与否,决定下一患者布托啡诺剂量增加或减少5μg·kg-1,布托啡诺预处理后5 min静脉推注罗库溴铵0.6 mg·kg-1,并评估疼痛情况,用Probit概率单位回归法计算布托啡诺预防罗库溴铵注射痛的半数有效剂量(ED 50)和95%有效剂量(ED 95)及相应的95%置信区间。结果布托啡诺预防罗库溴铵注射痛的ED 50为23.66μg·kg-1,95%置信区间为14.75~29.99μg·kg-1;ED 95为40.30μg·kg-1,95%置信区间为32.44~107.42μg·kg-1。结论预注40.30μg·kg-1的布托啡诺可有效预防95%的患者静脉注射罗库溴铵时产生的注射痛。 Objective To explore the dose-response relationship of butorphinol in preventing rocuronium induced injection pain.Methods Thirty-six adult patients with ASAⅠ~Ⅱwere selected for elective surgery under general anesthesia.Butorphinol was pretreated intravenously in all patients,and the initial dose was set at 30μg·kg-1.Dixon modified sequential method was used to determine whether the dose of butorphinol was increased or decreased by 5μg·kg-1 in the next patient according to the occurrence of rocuronium injection pain in the previous patient.After 5 min of butorphinol pretreatment,the intravenous injection of rocuronium was 0.6 mg·kg-1,and the pain was evaluated.Probit probability unit regression method was used to calculate 50%effective dose(ED 50)and 95%effective dose(ED 95)of butorphinol in preventing rocuronium injection pain and corresponding 95%confidence interval.Results The ED 50 of butopenol was 23.66μg·kg-1 and the 95%confidence interval was 14.75~29.99μg·kg-1;ED 95 was 40.30μg·kg-1,and the 95%confidence interval was 32.44~107.42μg·kg-1.Conclusion Preinjection of 40.30μg·kg-1 butorphinol can effectively in preventing rocuronium injection pain rocuronium in 95%of patients.
作者 毛珊珊 张晗 刘琨 郑孝振 陈勇 洪道先 MAO Shan-shan;ZHANG Han;LIU Kun;ZHENG Xiao-zhen;CHEN Yong;HONG Dao-xian(The First Affiliated Hospital of Henan University,Kaifeng 475001,China)
出处 《河南医学研究》 CAS 2020年第30期5598-5600,共3页 Henan Medical Research
关键词 布托啡诺 罗库溴铵 注射痛 量效关系 butorphanol rocuronium injection pain does-response relationship
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