摘要
目的探讨环丙孕酮联合吡格列酮治疗多囊卵巢综合征的临床疗效。方法选取射洪市中医院2017年1月—2018年6月收治的多囊卵巢综合征患者150例,随机分为对照组与观察组,每组75例。对照组予以环丙孕酮治疗,观察组在对照组基础上联合吡格列酮治疗。两组均治疗3个月经周期。比较两组治疗前后空腹胰岛素(FINS)、空腹血糖(FPG)、胰岛素抵抗指数(HOMA-IR)、胰岛素分泌指数(HOMA-β)、雌二醇(E2)、黄体生成素(LH)、促卵泡生成素(FSH)、性激素结合蛋白(SHBG)、去氢表雄酮硫酸盐(Ds)、雄烯二酮(A2)、睾酮(T),并观察两组不良反应发生情况。结果治疗前两组FINS、FPG、HOMA-IR、HOMA-β、E2、LH、FSH、SHBG、Ds、A2、T比较,差异无统计学意义(P>0.05);治疗后观察组FINS、FPG、HOMA-IR、HOMA-β、E2、LH、FSH、Ds、A2、T低于对照组,SHBG高于对照组(P<0.05)。两组均未发生明显不良反应。结论环丙孕酮联合吡格列酮治疗多囊卵巢综合征的临床疗效确切,可有效改善胰岛素抵抗,降低患者性激素,且安全性较高。
Objective To analyze the clinical effect of cyproterone combined with pioglitazone on polycystic ovary syndrome.Methods A total of 150 cases of patients with polycystic ovary syndrome were selected from January 2017 to June 2018 in Shehong Municipal Hospital of Traditional Chinese Medicine,which were randomly divided into control group and observation group,75 cases in each group.The control group was treated with cyproterone,the observation group was treated with pioglitazone based on the control group.Fasting insulin(FINS),fasting blood glucose(FPG),insulin resistance index(HOMA-IR),insulin secretion index(HOMA-β),estradiol(E2),luteinizing hormone(LH),follicle stimulating hormone(FSH),sex hormone binding protein(SHBG),dehydroepiandrosterone sulfate(Ds),androstenedione(A2),testosterone(T)before and after treatment were compared between the two groups,and the incidence of adverse reactions were observed.Results Before treatment,there was no significant difference in FINS,FPG,HOMA-IR,HOMA-β,E2,LH,FSH,SHBG,Ds,A2 and T between the two groups(P>0.05).After treatment,FINS,FPG,HOMA-IR,HOMA-β,E2,LH,FSH,Ds,A2,T in the observation group were lower than control group,while SHBG was higher than control group(P<0.05).No obvious adverse reactions occurred in the two groups.Conclusion Cyproterone combined with pioglitazone have an exact clinical effect for polycystic ovary syndrome,which can effectively improve and improve insulin resistance,reduce sex hormone of patients,and with high safety.
作者
李洁雅
白文
LI Jie-ya;BAI Wen(Department of Gynaecology and Obstetrics,Shehong Municipal Hospital of Traditional Chinese Medicine,Shehong 629200,China)
出处
《临床合理用药杂志》
2020年第18期20-22,共3页
Chinese Journal of Clinical Rational Drug Use
关键词
多囊卵巢综合征
环丙孕酮
吡格列酮
治疗结果
Polycystic ovary syndrome
Cyproterone
Pioglitazone
Treatment outcome
