摘要
目的分析儿童黑热病相关性噬血细胞性淋巴组织细胞增生症(HLH)的临床特征,以提高该病的临床诊断水平。方法收集2006年1月~2017年1月新疆维吾尔自治区人民医院儿科住院确诊的48例HLH患儿临床资料,根据黑热病及HLH的诊断标准分为黑热病相关性HLH组与非黑热病相关性HLH,比较两组流行病学资料、实验室检查指标。结果48例HLH患儿中黑热病相关性HLH患儿22例。两组年龄、性别、民族比较,差异无统计学意义(P>0.05);两组地域比较,差异有统计学意义(P<0.05);黑热病相关性HLH患儿春夏无发病,秋冬季患病比例高,而非黑热病相关性HLH患儿春夏秋冬四季都有发病。两组Hb、WBC、ALB、TBIL、TG、PT、APTT、Fib、血清钠比较,差异无统计学意义(P>0.05);两组Plt、AST、ALT、LDH比较,差异有统计学意义(P<0.05)。结论秋冬季来自南疆的HLH患儿应警惕黑热病相关性HLH,黑热病相关性HLH肝功能损害较非黑热病相关性HLH更严重。
Objective To analyze the clinical features of childhood kala-azar-related hemophagocytic lymphohistiocytosis(HLH)in order to improve the clinical diagnosis of the disease.Methods The clinical data of 48 children with HLH diagnosed in the Pediatrics Department of Xinjiang Uygur Autonomous Region People's Hospital from January 2006 to January 2017 were collected.According to the diagnostic criteria of kala-azar and HLH,they were divided into kala-azar-related HLH group and non-kala-azar-related HLH.Two groups of epidemiological data,laboratory inspection indicators.Results Among the 48 children with HLH,22 were children with kala-azar-related HLH.There was no statistically significant difference between the two groups in age,gender,and ethnicity(P>0.05);Comparison of the two groups of regions,the difference was statistically significant(P<0.05);children with kala-azar-related HLH had no disease in spring and summer,and the incidence was high in autumn and winter,while children with non-kala-azar-related HLH had disease in spring,summer,autumn and winter.There was no significant difference between the two groups of Hb,WBC,ALB,TBIL,TG,PT,APTT,Fib,and serum sodium(P>0.05);the difference between the two groups of Plt,AST,ALT,LDH was statistically significant(P<0.05).Conclusion In autumn and winter,children with HLH from southern Xinjiang should be alert to kala-azar-related HLH.The liver function damage of kala-azar-related HLH was more serious than that of non-kala-azar-related HLH.
作者
王乔宇
龚政
罗新辉
WANG Qiao-yu;GONG Zheng;LUO Xin-hui(Department of Pediatrics,Hangzhou Children's Hospital,Hangzhou 310000,Zhejiang,China;Department of Preventive Health,Hangzhou Binjiang District Maternal and Child Health Hospital,Hangzhou 310000,Zhejiang,China;Department of Pediatrics,Children's Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830000,Xinjiang,China)
出处
《医学信息》
2020年第21期109-111,共3页
Journal of Medical Information
