摘要
目的:比较多发性硬化(multiple sclerosis,MS)和视神经脊髓炎谱系疾病(neuromyelitis optica spectrum disorder,NMOSD)中复发性视神经炎(recurrent optic neuritis,RON)的发病特点。方法:回顾性分析保定市第一中心医院17例MS和24例NMOSD患者RON的发病特点,比较两组患者同侧视神经炎(optic neuritis,ON)的复发率。结果:MS组和NMOSD组中ON的发病年龄、性别、发作次数、视盘水肿发生率的差异无统计学意义(P>0.05)。两组患者首次发作ON都以单眼发病多见(94.12%vs 87.5%,χ^2=0.495,P=0.629),NMOSD组较MS组最终双眼发病多见(85.33%vs 35.29%,χ^2=0.495,P=0.02),视力重度受损(最佳矫正视力<0.1)比例高(58.33%vs 29.41%,χ^2=4.894,P=0.027)。MS组全病程以单眼发病为主,MS组的同侧ON复发率高于NMOSD组(70.58%vs 29.16%,χ^2=10.15,P=0.009)。结论:RON在MS和NMOSD中有不同的发病特点。NMOSD以双眼先后发病为主,而MS全病程以同侧单眼ON多见。与NMOSD中双眼随机发作ON不同,MS相关性RON更倾向于累及之前受损眼。
Objective:To compare the characteristics of recurrent optic neuritis(RON)in multiple sclerosis(MS)and neuromyelitis optica spectrum disorder(NMOSD).Methods:Seventeen MS and 24 NMOSD patients with RON were retrospectively analyzed in Baoding First Central Hospital.The recurrence rates of ipsilateral ON between MS and NMOSD were compared.Results:There was no significant difference in age,gender,numbers of ON events and incidence of optic disc edema between MS and NMOSD(P>0.05).Both 2 groups presented more frequently with unilateral involvement at their first ON attack(94.12%vs 87.5%,χ^2=0.495,P=0.629).Compared with MS,NMOSD patients showed a higher frequency of bilateral eyes involved at the final course(85.33%vs 35.29%,χ^2=0.495,P=0.02)and the vision impairment was severer in NMOSD patients(58.33%vs 29.41%,χ^2=4.894,P=0.027).The unilateral ON was more common in MS during the whole course and the recurrence rate of ipsilateral eye in MS was higher than that in NMOSD(70.58%vs 29.16%,χ^2=10.15,P=0.009).Conclusion:The characteristics of RON have differs between MS and NMOSD.NMOSD patients tend to have bilateral ON successively while ipsilateral and unilateral ON is more common in MS during the whole course.The recurrence rate of ipsilateral eye in MS is significantly higher than that in NMOSD.Unlike binocular random ON in NMOSD,ON in MS tends to involve the same eye affected in the previous episodes.
作者
许晓颖
李宁
韦秋红
XU Xiaoying;LI Ning;WEI Qiuhong(First Department of Ophthalmology,Baoding First Central Hospital,Baoding Hebei 071000;Second Department of Neurology,Affiliated Hospital of Hebei University,Baoding Hebei 071000,China)
出处
《临床与病理杂志》
2020年第10期2661-2665,共5页
Journal of Clinical and Pathological Research
关键词
复发性视神经炎
多发性硬化
视神经脊髓炎谱系疾病
recurrent optic neuritis
multiple sclerosis
neuromyelitis optica spectrum disorder
