摘要
报道了一个通过β,γ-炔基α-亚胺酸酯的化学和对映选择性转移氢化反应来合成光学纯β,γ-炔基α-氨基酸酯的方法.该不对称还原反应所展示出的优秀的化学选择性是由手性磷酸作为催化剂以及苯并噻唑啉作为氢负供体实现的.反应展示出了良好的官能团兼容性,高对映选择性地合成了一系列光学活性的非天然氨基酸酯化合物.
An effective chemo-and enantioselective transfer hydrogenation ofβ,γ-alkynylα-imino esters to prepare optically pureβ,γ-alkynylα-amino esters has been described.The excellent chemoselectivity was achieved by using chiral phosphoric acid catalyzed asymmetric reduction with benzothiazoline as hydride donor.The reaction exhibited good functional group tolerance,providing a range of optically active non-natural amino esters with excellent enantioselectivity.
作者
张璐
刘爱芹
刘华铮
万仁忠
孙书涛
刘磊
Zhang Lu;Liu Aiqin;Liu Huazheng;Wan Renzhong;Sun Shutao;Liu Lei(College of Animal Science and Veterinary Medicine,Shandong Agricultural University,Taian,Shandong 271018;School of Chemistry and Chemical Engineering,Shandong University,Jinan 250100;Institute of Materia Medica,Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan 250062)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2020年第9期2904-2911,共8页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(Nos.21722204,21971148)资助项目.
