摘要
目的:探讨Treg细胞及Th17细胞的变化与儿童再生障碍性贫血临床预后的相关性。方法:回顾性分析2017年1月至2018年1月在首都医科大学附属北京儿童医院应用抗胸腺细胞球蛋白(ATG)联合环孢素免疫抑制治疗(IST)的13例再生障碍性贫血(AA)患儿的临床资料。对比分析IST前和IST后6、12个月AA患儿外周血中Treg细胞及Th17细胞表达水平的变化,采用SPSS 19.0统计软件进行数据分析。结果:与IST前对比,IST后6个月Treg细胞表达水平明显降低,差异具有统计学意义(P<0.01);而Th17细胞表达水平与IST前相比无统计学差异。与IST前对比,IST后12个月Treg和Th17细胞表达水平均明显降低(P<0.01),但IST后6个月、IST后12个月Treg细胞/Th17细胞比值无明显变化。结论:IST有效的AA患儿外周血Treg细胞、Th17细胞表达减少,调节性T细胞及Th17细胞的变化与儿童AA的临床预后有相关性。
Objective:To explore the correlation between the of regulatory T cells,Th17 cells and the prognosis of children with aplastic anemia.Methods:The clinical data 13 children with aplastic anemia(AA)treated by antithymocyte globulin(ATG)combined with Cyclosporine in Beijing Children′s Hospital,Capital Medical University from January2017 to January 2018 were analyized retrospectively.The changes of T cell and Th17 cell expression level in peripheral blood of AA children before and after IST for 6 and 12 month were compared and analyzed.The SPSS 19.0 statistical package was used for data analysis.Results:Compared with the pre-IST,the expression level of Treg cells decreased at 6 months of IST,the difference was statistically significant(P<0.05);however the expression level of Th17 cells did not show significant difference as compared with that pre-IST.The expression level of Treg and Th17 cells at 12 months of IST was lower than that pre-IST(P<0.01),compared with the level pre-IST,the ratio of Treg cells/Th17 cell at 6 months and 12 months of IST did not show a singificand difference.Conclusion:Treg cells and Th17 cells in peripheral blood of AA children decrease after IST,which suggests that the change of regulatory T cells and Th17 cells correlate with the clinical outcome of children with aplastic anemia.
作者
赵莎莎
朱筱旌
吴润晖
ZHAO Sha-Sha;ZHU Xiao-Jing;WU Run-Hui(Beijing Key Laboratory of Pediatric Hematology Oncology,National Key Discipline of Pediatrics(Capital Medical University),Key Laboratory of Major Diseases in Children,Ministry of Education,Hematology Oncology Center,Beijing Children′s Hospital,Capital Medical University,National Center for children′s Health,Beijing 100045,China)
出处
《中国实验血液学杂志》
CAS
CSCD
北大核心
2020年第5期1674-1678,共5页
Journal of Experimental Hematology
基金
国家自然科学基金课题(81970111)
北京市自然科学基金课题(项目编号:7192064)
北京市医院管理局儿科学科协同发展中心“儿科专项”(项目编号:XTZD20180205)
北京市医管中心临床医学发展专项(ZY201404)
国家科技重大专项(2017ZX09304029004)。
