摘要
目的探讨升陷袪瘀汤联合厄贝沙坦、阿托伐他汀对高血压患者中医证候积分、血脂水平及血压变异性的影响。方法采用前瞻性研究,选择2016年3月至2019年3月滁州市第一人民医院收治的80例高血压患者作为对象,按照随机数字表法,随机分为观察组和对照组各40例,其中对照组采用厄贝沙坦、阿托伐他汀治疗,观察组在此基础上配合升陷祛瘀汤治疗,治疗结束后比较两组患者的中医证候疗效、相关血脂指标、血压变异性的改善程度,以观察祛瘀升陷汤治疗气陷血瘀型高血压病的临床疗效。结果观察组中医证候疗效总有效率92.5%明显高于对照组的70.0%,且差异有统计学意义(P<0.05);与治疗前相比,两组SBP治疗后均明显降低(P<0.05),而两组DBP治疗前后差异均无统计学意义(P>0.05).两组治疗后SBP及DBP比较差异均无统计学意义(P>0.05);与治疗前相比,治疗后两组24 h收缩压标准差(24 h SSD)、白天收缩压标准差(dSSD)、夜间收缩压标准差(nSSD)均明显下降(P<0.05),24 h舒张压标准差(24 h DSD)、白天舒张压标准差(dDSD)、夜间舒张压标准差(nDSD)则差异均无统计学意义(P>0.05)。与对照组相比,观察组24 h SSD、dSSD、nSSD水平均明显降低(P<0.05),而两组24 h DSD、dDSD、nDSD则差异均无统计学意义(P>0.05);治疗后两组TC、TG、LDL水平均明显降低,差异有统计学意义(P<0.05),且观察组明显低于对照组(P<0.05)。结论升陷祛瘀汤治疗气陷血瘀型高血压疗效显著,可有效改善血压变异性及血脂水平。
Objective To investigate the effect of Shengxian decoction combined with irbesartan and atorvastatin on tranditonal Chinese medicine(TCM)efficacy,blood lipid levels and blood pressure variability in patients with hypertension.Methods This study prospectively selected 80 cases of hypertension patients in Chuzhou First Peoples Hospital from March 2016 to March 2019 as the objects,and were randomly divided into observation group and control group with 40 cases in each group.The control group was treated with irbesartan and atorvastatin,and the observation group was treated with Shengxian decoction on the basis of the treatment.After the treatment,the TCM efficacy,related blood lipids and improvement of blood pressure variability of the two groups were compared.Results The total effective rate of TCM syndrome in the observation group(92.5%)was significantly higher than that in the control group(70.0%),with statistically significant difference(P<0.05);compared with before treatment,the systolic blood pressure(SBP)in both groups was significantly decreased(P<0.05),but there was no significant difference in diastolic blood pressure(DBP)between the two groups before iind after treatment(P>0.05);there was no significant difference in SBP and DBP between the two groups after treatment(P<0.05).Compared with that before treatment,24 h standard deviation of systolic blood pressure(24 h SSD),day standard deviation of systolic blood pressure(dSSD)and night standard deviation of systolic blood pressure(nSSD)in the two groups were significantly decreased(P<0.05),while there was no significant difference in 24 h standard deviation of diastolic blood pressure(24 h DSD),day standard deviation of diastolic blood pressure(nDSD)and night standard deviation of diastolic blood pressure(nDSD)between the two groups(P>0.05).Compared with the control group,the levels of 24 h SSD,dSSD and nSSD in the obsenation group were significantly lower(P<0.05),while there was no significant difference in 24 h DSD,dDSD,nDSD between the two groups(P>0.05)
作者
徐华庆
蔡兴慧
陆明奎
卓雪莉
高磅礴
林中军
Xu Huaqing;Cai Xinghui;Lu Mingkui;Zhuo Xueli;Gao Pangbo;Lin Zhongjun(Department of hitegrated Traditional Chinese and Western Medicine,Chiizhou First People's Hospital,Chuzhou 239000,China;College of Acupuncture and Massage,Anhui University of Traditional Chinese Medicine,Hefei 230038,China)
出处
《中国医师杂志》
CAS
2020年第10期1483-1487,共5页
Journal of Chinese Physician
基金
国家自然科学基金(81503658)。
关键词
高血压
升陷祛瘀汤
血压变异性
血脂
中医症候积分
Hypertension
Shengxian decoction
Blood pressure variability
Blood lipids
FCM syndrome scores
