摘要
目的研究小柴胡汤抗抑郁作用及其对脑内神经递质、神经营养因子和雌性激素的影响。方法将医院2017年1月—2018年10月诊治的抑郁患者134例,遵照知情同意原则并按随机数字表法分为对照组和观察组,每组67例,对照组采用常规西药治疗,观察组采用小柴胡汤治疗,观察比较两组的治疗效果以及患者脑内神经递质、神经营养因子和雌性激素变化情况和不良反应发生率。结果观察组总有效率为97.0%(65/67),显著高于对照组的85.1%(57/67),组间差异有统计学意义(P<0.05);治疗前两组脑内神经递质多巴胺(DA)、去甲肾上腺素(NE)、5-羟色胺(5-HT)、乙酰胆碱(Ach)比较均差异无统计学意义(P>0.05),治疗后观察组DA、NE、5-HT均显著优于对照组(P<0.05);治疗前两组神经营养因子比较无显著性差异(P>0.05),治疗后观察组神经营养因子情况显著优于对照组(P<0.05);治疗前两组雌性激素雌二醇(E2)、孕酮(P)比较差异无统计学意义(P>0.05),治疗后观察组血清E2、P水平显著高于对照组(P<0.05);观察组不良反应发生率为9.0%(6/67),略低于对照组的13.4%(9/67),差异无统计学意义(P>0.05),两组不良反应均较轻微、可自行缓解。结论小柴胡汤抗抑郁作用显著,能够维持脑内神经递质的稳态、增强神经营养、调节雌性激素水平,可以作为抑郁患者的优选治疗方案之一。
Objective To study the anti-depression effect of Xiaochaihu Decoction and its effect on neurotransmitters,neurotrophic factor and estrogen in the brain.Methods A total of 134 patients with depression in our hospital from January 2017 to October 2018 were divided into the control group and the observation group according to the principle of informed consent,67 cases in each group.The control group was treated with conventional western medicine and the observation group was treated with Xiaochaihu Decoction.The treatment effect,changes of neurotransmitters,neurotrophic factors and estrogens in the brain of two groups were observed and compared.Results The total effective rate of the observation group was 97.0%(65/67),which was significantly higher than 85.1%(57/67)of the control group.There was significant difference between two groups(P<0.05).There were no significant differences in neurotransmitter dopamine(DA),norepinephrine(NE),5-hydroxytryptamine(5-HT)or acetylcholine(Ach)between two groups before treatment(P>0.05).After treatment,DA,NE and 5-HT of the observation group were significantly better than those of the control group(P<0.05).There were no significant differences in neurotrophic factors between two groups before treatment(P>0.05).After treatment,the neurotrophic factors of the observation group were significantly better than those of the control group(P<0.05).There were no significant differences in estrogen estradiol(E2)or progesterone(P)of two groups before treatment(P>0.05).The levels of serum E2 and P of the observation group were significantly higher than those of the control group(P<0.05).The incidence of adverse reactions of the observation group was 9.0%(6/67),which was slightly lower than 13.4%(9/67)of the control group,and the difference was not statistically significant(P>0.05).The adverse reactions in both groups were mild and could be relieved by themselves.Conclusion Xiaochaihu Decoction has significant anti-depression effect,and can maintain the steady state of neurotransmitters in brai
作者
苏丽娟
王娟
刘旭恩
王清溪
SU Lijuan;WANG Juan;LIU Xuen;WANG Qingxi(Department of Early Intervention,The Second Hospital of Xinxiang Medical College,Xinxiang 453002,Henan,China)
出处
《中华中医药学刊》
CAS
北大核心
2020年第9期38-40,共3页
Chinese Archives of Traditional Chinese Medicine
基金
国家中医药管理局中医药科学技术研究专项(2017ZX931)。
关键词
抑郁
小柴胡汤
神经递质
神经营养因子
雌性激素
depression
Xiaochaihu Decoction
neurotransmitter
neurotrophic factor
estrogen
