摘要
目的探究混合调强放疗技术在乳腺癌治疗中的应用价值。方法抽取2019年1月至2019年4月山西省肿瘤医院收治的96例乳腺癌患者作为研究对象,采用随机数字表法将其为对照组和研究组,每组48例。对照组予以单纯调强放射治疗,研究组予以混合调强放射治疗。统计比较两组计划靶区(PTV)评价参数[最大剂量(Dmax)、平均剂量(Dmean)、最小剂量(Dmin)、适形指数(CI)、均匀性指数(HI)、机器总跳数(MU)]、周围正常器官评价参数[全肺Dmean、5 Gy剂量体积(V5)、V20及心脏Dmean、V20、V40]、血清血管内皮生长因子(VEGF)、糖类抗原125(CA125)水平、免疫功能(CD4+/CD8+、CD19+、CD56+)、放射性心肺损伤发生率及生存质量。结果研究组HI、MU低于对照组(P<0.05);研究组全肺Dmean、V5、V20及心脏Dmean、V20均低于对照组,心脏V40高于对照组(P<0.05)。治疗后,研究组血清VEGF、CA125水平均低于对照组(P均<0.05);研究组CD4+/CD8+、CD19+、CD56+均高于对照组(P均<0.05)。研究组放射性肺损伤发生率(4.17%,2/48)低于对照组(18.75%,9/48),P<0.05。治疗后3个月,研究组生存质量改善率(58.33%,28/48)高于对照组(35.42%,17/48),P<0.05。结论乳腺癌患者采用混合调强放疗技术治疗,能显著提高靶区剂量分布的均匀性并减少机器磨损,减少对机体免疫功能的影响,降低放射性肺损伤发生率,且能改善抗肿瘤效果,提高患者生存质量。
Objective To investigate the application value of mixed intensity modulated radiotherapy for breast cancer.Methods A total of 96 cases of breast cancer patients treated in Tumor Hospital of Shanxi from January 2019 to April 2019 were selected as the research objects.And they were divided into control group and study group by random number table method,with 48 cases in each group.The control group received simple intensity-modulated radiation therapy,and the study group received mixed intensity-modulated radiation therapy.The planning target volume(PTV)evaluation parameters,including maximum dose(Dmax),mean dose(Dmean),minimum dose(Dmin),conformity index(CI),uniformity index(HI),total machine hops(MU),the evaluation parameters of normal organs around,such as whole lung Dmean,5 Gy dose volume(V5),V20 and heart Dmean,V20,V40,serum vascular endothelial growth factor(VEGF),carbohydrate antigen 125(CA125),immune function including cluster of differentiation(CD)4+/CD8+,CD19+,CD56+,incidence of radiation-induced cardiopulmonary injury and quality of life were compared between the two groups.Results HI and MU in the study group were lower than those in the control group(P<0.05);the whole lung Dmean,V5,V20 and heart Dmean,V20 of the study group were lower than those in the control group,and the heart V40 was higher than that in the control group(P<0.05).After treatment,the levels of serum VEGF and CA125 in the study group were lower than those in the control group(P<0.05);CD4+/CD8+,CD19+,and CD56+in the study group were higher than those in the control group(all P<0.05).The incidence of radiation lung injury in the study group(4.17%,2/48)was lower than that in the control group(18.75%,9/48),P<0.05.The improvement rate of quality of life in the study group(58.33%,28/48)was higher than that in the control group(35.42%,17/48),P<0.05.Conclusions Breast cancer patients treated by mixed intensity modulated radiotherapy can significantly improve the uniformity of the dose distribution in the target area,reduce the wear of the mac
作者
马永强
蒋倩
马琴
Ma Yongqiang;Jiang Qian;Ma Qin(Department of Mammary Radiation,Tumor Hospital of Shanxi,Taiyuan 030013,China)
出处
《中国实用医刊》
2020年第19期29-33,共5页
Chinese Journal of Practical Medicine
关键词
乳腺癌
混合调强放疗
放射性心肺损伤
免疫功能
血管内皮生长因子
糖类抗原125
Breast cancer
Mixed intensity modulated radiotherapy
Radiation cardiopulmonary injury
Immune function
Vascular endothelial growth factor
Carbohydrate antigen 125
