摘要
目的:从中医证候要素及证型分布对慢性乙型肝炎(CHB)患者乏力症状的中医病机特点进行初步分析。方法:采集234名以乏力为主诉的CHB患者中医证候积分量表和疲劳量表的积分,通过Spearman相关、聚类分析等手段评价乏力程度与证候要素、证型之间的相关性。结果:所有证候要素都能引起不同程度的疲劳,躯体疲劳积分与脾虚(rs=0.348)、肾阴虚(rs=0.289)、肝郁(rs=0.255)相关性大(P<0.05);肝肾阴虚证的积分与疲劳总分(rs=0.329)、躯体疲劳积分(rs=0.279)正相关(P<0.05);聚类分析发现证型可分为四类,以肝肾阴虚证和肝郁脾虚证为主。结论:常见CHB的证候要素均可导致乏力症状的加重,但与肝郁、脾虚、肾阴虚的证候要素相关性最显著,主要表现在躯体疲劳上。CHB肝肾阴虚证、肝郁脾虚证患者更易出现乏力症状。
Objective:From the perspective of syndrome elements and syndrome types distribution,the pathogenesis of chronic hepatitis B(CHB)patients with fatigue symptoms were preliminarily analyzed.Methods:The Traditional Chinese Medicine syndrome score scale and 14item fatigue scale scores of 234 CHB patients were collected,and the correlation between fatigue degree,syndrome elements and types was compared using Spearman correlation and cluster analysis.Results:All syndrome elements can cause different degrees of fatigue.Physical fatigue scores were significantly correlated with spleen deficiency(rs=0.348),kidney Yin deficiency(rs=0.289),and liver depression(rs=0.255)(P<0.05).The scores of liverkidney Yin deficiency syndrome were positively correlated with the fatigue total score(rs=0.329)and the physical fatigue score(rs=0.279)(P<0.05).Cluster analysis shows syndrome types were classified into four clusters,mainly with liverkidney Yin deficiency and liverqi depression and spleen deficiency.Conclusion:The common syndrome elements of CHB can lead to the aggravation of fatigue symptom,and the physical fatigue was significantly correlated with the syndrome elements of liver depression,spleen deficiency and kidney Yin deficiency.CHB patients with liverkidney Yin deficiency and liverqi depression and spleen deficiency are more prone to fatigue symptoms.
作者
郑彦希
孙学华
张景豪
朱晓骏
高月求
ZHENG Yanxi;SUN Xuehua;ZHANG Jinghao;ZHU Xiaojun;GAO Yueqiu(Department of Hepatology,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine)
出处
《中西医结合肝病杂志》
CAS
2020年第5期402-404,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
基金
国家科技重大专项艾滋病和病毒性肝炎等重大传染病防治(No.2018ZX10725-504)
国家自然科学基金项目(No.81774256)。
关键词
慢性乙型肝炎
乏力
中医病机
chronic hepatitis B
fatigue
Traditional Chinese Medicine pathogenesis
