摘要
目的研究血液灌流联合纳洛酮对重度镇静催眠药中毒患者的疗效及安全性。方法纳入我院收治的重度镇静催眠药中毒患者60例,依据治疗方法的不同,分为对照组和观察组各30例。对照组给予常规治疗,观察组在对照组的基础上行血液灌流联合纳洛酮治疗。比较2组患者的治疗效果、恢复情况、临床指标和安全性。结果对照组的治疗优良率明显低于观察组(P<0.05)。对照组的苏醒时间、血药浓度正常时间和住院时间均明显高于观察组(P<0.05)。治疗后,2组的动脉血二氧化碳分压(PaCO2)、平均动脉压(MAP)、心率和格拉斯昏迷评分(GLAS)均明显改善(P<0.05),其中观察组PaCO2、MAP、心率和GLAS评分的变化明显优于对照组(P<0.05)。对照组的并发症发生率明显高于观察组(P<0.05)。结论血液灌流联合纳洛酮治疗重度镇静催眠药中毒,能够有效提高治疗效果,促进患者的快速恢复以及临床指标的改善,且安全性较好,值得在临床中推广应用。
Objective To study the efficacy and safety of hemoperfusion combined with naloxone in patients with severe sedative-hypnotics poisoning.Methods Sixty patients with severe sedative-hypnotics poisoning were included in our hospital.They were divided into control group and observation group according to different treatmentmethods,30 cases in each group.The control group was given conventional treatment,and the observation group received hemoperfusion combined with naloxone on the basis of treatment in the control group.The treatment effect,recovery,clinical indicators and safety of the two groups of patients were compared.Results The excellent treatment rate in the control group was significantly lower than that in the observation group(P<0.05).The awake time,normal blood concentration time,and hospital stay of the control group were significantly higher than those of the observation group(P<0.05).After treatment,PaCO2,MAP,heart rate,and GLAS scores were significantly improved in both groups(P<0.05).PaCO2,MAP,heart rate,and GLAS scores in the observation group were significantly better than those in the control group(P<0.05).The incidence of complications in the control group was significantly higher than that in the observation group(P<0.05).Conclusion Hemoperfusion combined with naloxone in the treatment of patients with severe sedative-hypnotics poisoning can effectively improve the treatment effect,promote the rapid recovery of patients and improve the clinical indicators,and has good safety,which is worth popularizing and applying in clinical practice.
作者
马蕾
王文娟
Ma Lei;Wang Wenjuan(Emergency Department,Luoyang General Hospital,Henan 471003,China;不详)
出处
《山西医药杂志》
CAS
2020年第20期2741-2743,共3页
Shanxi Medical Journal
关键词
血液灌流
纳洛酮
重度镇静
催眠药中毒
安全性
Hemoperfusion
Naloxone
Severe sedation
Sleeping drug poisoning
Safety
