摘要
目的:系统评价ABCB1 C3435T基因多态性与氯吡格雷抵抗(clopidogrel resistance)的相关性。方法:检索万方数据库、中国生物医学文献数据库、中国期刊全文数据库、中文科技期刊全文数据库(VIP)以及英文数据库Science Citation Index(SCI)、PubMed、EMBase等,检索年限从建库至2019年10月。对符合纳入标准的临床研究进行质量评价,使用Stata 14.0软件对提取的数据进行荟萃(meta)分析。结果:最终纳入10篇文献,2642例患者,其中氯吡格雷抵抗组878例、非氯吡格雷抵抗组1764例。分析结果显示,基于ABCB1 C3435T基因多态性,其各亚组整体效应均具有统计学意义(P<0.05):等位基因模型OR=1.39,95%CI(1.07,1.81);显性基因模型OR=1.37,95%CI(1.13,1.66);隐性基因模型OR=1.62,95%CI(1.02,2.57);纯合基因模型OR=1.92,95%CI(1.14,3.22);杂合基因模型OR=1.33,95%CI(1.06,1.66)。结论:现有证据表明,ABCB1 C3435T基因多态性与氯吡格雷抵抗具有相关性。
Objective:To systematically evaluate the correlation between ABCB1 C3435T gene polymorphism and clopidogrel resistance(CR).Methods:The databases,such as Wanfang Data,the Chinese Biomedical Literature Database(CBM),the Chinese Journal Fulltext Database in China National Knowledge Infrastructure(CNKI),the China Science and Technology Journal Database(VIP),Science Citation Index(SCI),PubMed and EMBase,were searched from the inception to October 2019.The quality of clinical studies which met the inclusion criteria was evaluated,and meta analysis was performed using Stata 14.0 software.Results:Ten papers were included and 2642 patients were enrolled,including 878 cases in the clopidogrel-resistance group and 1764 cases in the non-clopidogrel resistance group.Results of meta-analysis showed that due to ABCB1 C3435T gene polymorphism,the overall effect of each subgroup was statistically significant(P<0.05):allele gene model OR=1.39,95%CI(1.07,1.81),dominant gene model OR=1.37,95%CI(1.13,1.66),recessive gene model OR=1.62,95%CI(1.02,2.57),homozygous gene model OR=1.92,95%CI(1.14,3.22),and heterozygous gene model OR=1.33,95%CI(1.06,1.66).Conclusion:Current findings confirmed that ABCB1 C3435T gene polymorphism is associated with clopidogrel resistance.
作者
李剑钦
杨星辰
史蔚青
LI Jianqin;YANG Xingchen;SHI Weiqing(Department of Pharmacy,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)
出处
《药学服务与研究》
CAS
2020年第5期330-335,共6页
Pharmaceutical Care and Research
基金
上海中医药大学附属龙华医院自然科学研究基金(Y1817)。
