摘要
目的:探讨不同促甲状腺激素(Thyroid stimulating hormone,TSH)切点的多囊卵巢综合征(Polycystic ovary syndrome,PCOS)患者其代谢参数、胰岛素水平和性激素的差别。方法:收集195名PCOS患者,均行75 g葡萄糖负荷试验,并测定血糖、血脂、胰岛素及性激素,以稳态模型评估(Steady state model assessment,HOMA)评估胰岛素抵抗。所有的统计分析采用SPSS20.0。结果:无论是否经身体质量指数(Body mass index,BMI)及年龄较正,TSH≥2.5的PCOS患者与TSH<2.5的PCOS患者,60分钟血糖明显降低,30分钟胰岛素分泌明显升高,差异有统计学意义(P<0.05);经BMI及年龄较正后,TSH≥2.5的PCOS患者与TSH<2.5的PCOS患者比较180分钟血糖明显降低,孕酮水平明显降低,差异有统计学意义(P<0.05);无论是否经BMI及年龄较正,TSH≥4的PCOS患者与TSH<4的PCOS患者的比较,180分钟胰岛素水平均明显升高,差异有统计学意义(P<0.05)。结论:不同TSH切点PCOS者其胰岛素分泌模式及血糖、胰岛素水平存在差别;TSH大于4的PCOS患者其180分钟的胰岛素分泌水平明显增加,孕酮分泌水平明显降低。
Objective: To investigate the differences of metabolic parameters, insulin levels and sex hormones in patients with polycystic ovary syndrome(PCOS) at different Thyroid stimulating hormone(TSH) cut points. Methods: 195 PCOS patients were collected. All patients were tested with 75 g glucose load test, the blood glucose, blood lipid, insulin and sex hormone, and insulin resistance was assessed, and the evaluation of insulin resistance by steady state model assessment(HOMA). Spss20.0 was used for all statistical analysis. Results: Whether body mass index(BMI) or age is correct, in PCOS patients with TSH ≥ 2.5 and PCOS patients with TSH <2.5, the 60 minutes blood glucose were significantly decreased and 30 minutes insulin secretion significantly increased in 30 minutes, the difference were statistically significant(P<0.05);after BMI and age correction, compared with PCOS patients with TSH ≥ 2.5 and PCOS patients with TSH < 2.5, the 180 minutes blood glucose and progesterone levels were significantly lower, the difference were statistically significant(P<0.05);Whether BMI or age is correct, compared with PCOS patients with TSH ≥ 4 and PCOS patients with TSH < 4, the180 minutes insulin level in were significantly higher, the difference were statistically significant(P<0.05). Conclusion: The insulin secretion pattern, blood glucose and insulin level of PCOS patients with different TSH cut points were different;the insulin secretion level of PCOS patients with TSH≥4 increased significantly in 180 minutes, and the progesterone secretion level decreased significantly.
作者
赵红莉
韦洪江
刘桂治
黄翠英
周嘉
ZHAO Hong-li;WEI Hong-jiang;LIU Gui-zhi;HUANG Cui-ying;ZHOU Jia(Department of Endocrinology,Guangdong Provincial Second People's Hospital,Guangzhou,Guangdong,510317,China;Outpatient Department of Internal Medicine,Guangdong Provincial Second People's Hospital,Guangzhou,Guangdong,510317,China;Department of Laboratory,Guangdong Provincial Second People's Hospital,Guangzhou,Guangdong,510317,China;Department of Endocrinology,First Affiliated Hospital of Guangxi Medical University,Nanning,Guangxi,530000,China)
出处
《现代生物医学进展》
CAS
2020年第17期3264-3269,共6页
Progress in Modern Biomedicine
基金
广东省科技计划项目(2017ZC0284)。
关键词
多囊卵巢综合征
促甲状腺激素
胰岛素
血糖
Polycystic ovary syndrome
Thyroid stimulating hormone
Insulin
Blood sugar
