摘要
目的探讨雷公藤多苷治疗结缔组织病相关间质性肺病(CTD-ILD)的临床效果。方法选取2019年4~10月我院收治的40例CTD-ILD患者,按随机数字表法分为对照组和试验组,各20例。对照组采用糖皮质激素治疗,试验组在此基础上给予雷公藤多苷治疗。比较两组患者的临床治疗总有效率、肺功能改善情况、不良反应发生率。结果试验组的治疗总有效率为80.00%,高于对照组的65.00%,差异有统计学意义(P<0.05)。两组患者治疗前的肺总量(TLC)、CO弥散量(DLCO)、动脉血氧分压(PaO2)水平比较,差异无统计学意义(P>0.05);两组患者治疗后的TLC、DLCO和PaO2水平均高于治疗前,且试验组治疗后的TLC、DLCO和PaO2水平高于对照组(P<0.05)。试验组的药物不良反应发生率高于对照组(P<0.05)。结论雷公藤多苷联合激素治疗CTD-ILD的临床效果显著,能够明显改善患者肺功能,且不良反应发生率相对较低,可能成为CTD-ILD治疗的备选方案之一。
Objective To investigate the clinical efficacy of Tripterygium Glycosides in the treatment of connective tissue disease related interstitial lung disease(CTD-ILD).Methods A total of 40 patients with CTD-ILD admitted to our hospital from April to October 2019 were selected and randomly divided into the control group and the experiment group,with 20 cases in each group.The control group was treated with Glucocorticoids,and the experiment group was given Tripterygium Glycosides treatment on the basis of the control group.The clinical treatment efficiency,improvement of lung function,incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the experiment group was 80.00%,which was higher than 65.00%in the control group,the difference was statistically significant(P<0.05).Before treatment,there were no significant difference in the levels of total lung volume(TLC),CO diffusion(DLCO),and arterial oxygen partial pressure(PaO2)between the two groups(P>0.05).After treatment,the levels of TLC,DLCO,and PaO2 were higher than those before treatment in the two groups,and the levels of TLC,DLCO,and PaO2 in the experiment group were higher than those in the control group(P<0.05).The total incidence of drug side effect in the experiment group was lower than that in the control group(P<0.05).Conclusion Tripterygium Glycosides has a significant clinical effect on CTD-ILD,which can significantly improve the patient′s lung function,and has low incidence of adverse reactions.It may become one of the options in the treatment of CTD-ILD.
作者
陈琥
甘凤英
居艳娟
谷晓晶
李荣平
王飙
郭迪斌
CHEN Hu;GAN Feng-ying;JU Yan-juan;GU Xiao-jing;LI Rong-ping;WANG Biao;GUO Di-bin(Department of Rheumatology and Immunology,the First Affiliated Hospital of Gannan Medical College,Jiangxi Prouince,Ganzhou 341000,China)
出处
《中国当代医药》
2020年第29期32-34,共3页
China Modern Medicine
基金
江西省中医药科研课题(2019B079)。
关键词
雷公藤多苷
肺功能
临床效果
Tripterygium Glycosides
Lung function
Clinical efficacy
