摘要
目的分析青年大学生高尿酸血症与肥胖的相关性。方法2018年及2019年南京大学新生入校体检者19673人,根据体重指数分为低体重组、正常组、超重组和肥胖组。清晨空腹抽血检测丙氨酸转氨酶(ALT)、尿酸、尿素氮、肌酐。比较不同组别血尿酸和代谢指标的差异。利用Pearson相关分析、多元线性回归及logistic回归分析体重指数与高尿酸血症的相关性。结果青年大学生高尿酸血症的患病率为32.35%,其中男性患病率显著高于女性患病率(57.30%对6.51%,P<0.01)。随着体重指数的增高,高尿酸血症患病率显著升高(P趋势<0.01);且男、女性的血尿酸亦显著递增(P趋势<0.01)。无论男性还是女性,血尿酸与体重指数独立正相关(P<0.01)。将体重指数正常组中高尿酸血症人群作为参照组,校正性别、年龄、ALT、血尿素氮、血肌酐、估算的肾小球滤过率后,超重组和肥胖组的OR分别为2.30(95%CI 1.99~2.66)、4.35(95%CI 3.22~5.89),低体重组为0.70(95%CI 0.60~0.82)。结论青年学生高尿酸血症患病率高,肥胖是高尿酸血症的独立危险因素。
Objective To analyze the correlation between hyperuricemia and obesity in young college students.Methods A total of 19673 students receiving enrolment physical examinations in Nanjing University from 2018 to 2019 were included in the study.The subjects were divided into underweight,normal,overweight,and obesity groups according to their body mass index.Fasting blood were taken to detect alanine aminotransferase(ALT),serum uric acid,urea nitrogen,and creatinine.The differences between serum uric acid and metabolic parameters among different groups as well as the correlation between body mass index and hyperuricemia were analyzed by using multivariate linear regression and logistic regression analysis.Results The prevalence of hyperuricemia was 32.35%for the college students,while for the males it reached up to 57.30%that was significantly higher than female ones(6.51%,P<0.01).With the increasing of body mass index,the prevalence of hyperuricemia increased significantly(Ptrend<0.01),as well as serum uric acid in both male and female students(Ptrend<0.01).Serum uric acid was positively correlated with body mass index in both genders(P<0.01).The odds ratio(OR)and 95%confidence interval(CI)for overweight,obesity,and underweight body mass index groups were 2.30(95%CI 1.99-2.66),4.35(95%CI 3.22-5.89),and 0.70(95%CI 0.60-0.82),respectively,compared to the normal body mass index group by adjusting possible factors such as gender,age,ALT,urea nitrogen,creatinine,as well asestimated glomerular filtration rate.Conclusion The prevalence of hyperuricemia in young students is high.Obesity seems to be an independent risk factor of hyperuricemia.
作者
吴盈
柳蕊
唐少秋
韩莹莹
崔雯霞
高蕾
胡云
Wu Ying;Liu Rui;Tang Shaoqiu;Han Yingying;Cui Wenxia;Gao Lei;Hu Yun(Department of Geriatrics,Drum Tower Hospital Affiliated to Nanjing University Medical School,Nanjing 210008,China;Department of General Practice,Nanjing University Hospital,Nanjing 210093,China)
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2020年第9期773-777,共5页
Chinese Journal of Endocrinology and Metabolism
关键词
肥胖
体重指数
高尿酸血症
患病率
Obesity
Body mass index
Hyperuricemia
Prevalence
