摘要
目的观察分析盐酸氨溴索治疗重症肺炎并呼吸衰竭患者的临床效果。方法82例重症肺炎并呼吸衰竭患者,按照随机数字表法分为对照组和实验组,每组41例。两组患者均应用常规方法治疗,对照组单纯应用经鼻持续气道正压通气治疗,实验组应用盐酸氨溴索联合经鼻持续气道正压通气治疗。比较两组患者治疗前后血气指标(氧分压、血氧饱和度以及二氧化碳分压)以及临床指标(肺部啰音消失时间、住院时间以及经鼻持续气道正压通气治疗时间)、临床治疗效果。结果两组患者治疗前氧分压、血氧饱和度以及二氧化碳分压水平比较差异无统计学意义(P>0.05);治疗后,实验组患者的氧分压、血氧饱和度以及二氧化碳分压水平均明显优于对照组,差异具有统计学意义(P<0.05)。实验组患者的肺部啰音消失时间、住院时间以及经鼻持续气道正压通气治疗时间分别为(4.2±1.0)、(3.6±0.8)、(9.2±1.7)d,均明显短于对照组的(6.3±1.5)、(7.0±2.0)、(12.7±1.8)d,差异具有统计学意义(P<0.05)。实验组患者的临床治疗总有效率97.6%明显高于对照组的73.2%,差异具有统计学意义(P<0.05)。结论盐酸氨溴索联合经鼻持续气道正压通气治疗重症肺炎并呼吸衰竭患者的临床效果显著。
Objective To observe and analyze the clinical effect of ambroxol hydrochloride in the treatment of severe pneumonia with respiratory failure.Methods A total of 82 patients with severe pneumonia with respiratory failure were divided into control group and experimental group according to random numerical table,with 41 cases in each group.On the basis of conventional therapy,the control group was treated with nasal continuous positive airway pressure,and the experimental group was treated with ambroxol hydrochloride and nasal continuous positive airway pressure.The blood gas indexes(oxygen partial pressure,blood oxygen saturation,and carbon dioxide partial pressure)before and after treatment,clinical indicators(pulmonary rales disappearance time,hospitalization time,and nasal continuous positive airway pressure treatment time)and clinical effect were compared between the two groups.Results Before treatment,there was no statistically significant difference in oxygen partial pressure,blood oxygen saturation,and carbon dioxide partial pressure between the two groups(P>0.05).After treatment,the oxygen partial pressure,blood oxygen saturation,and carbon dioxide partial pressure of the experimental group were obviously better than those of the control group,and the difference was statistically significant(P<0.05).The pulmonary rales disappearance time,hospitalization time,and nasal continuous positive airway pressure treatment time of the experimental group were(4.2±1.0),(3.6±0.8)and(9.2±1.7)d,which were obviously shorter than(6.3±1.5),(7.0±2.0)and(12.7±1.8)d of the control group,and the difference was statistically significant(P<0.05).The total effective rate of clinical treatment 97.6%of the experimental group was obviously higher than 73.2%of the control group,and the difference was statistically significant(P<0.05).Conclusion Nasal continuous positive airway pressure combined with ambroxol hydrochloride shows remarkable clinical effect in the treatment of severe pneumonia with respiratory failure.
作者
何文宇
余文武
郭伟新
HE Wen-yu;YU Wen-wu;GUO Wei-xin(ICU,Zhuhai Hospital of People’s Hospital,Zhuhai 519090,China)
出处
《中国现代药物应用》
2020年第20期27-29,共3页
Chinese Journal of Modern Drug Application
关键词
盐酸氨溴索
经鼻持续气道正压通气
重症肺炎并呼吸衰竭
临床效果
Ambroxol hydrochloride
Nasal continuous positive airway pressure
Severe pneumonia with respiratory failure
Clinical effect
