摘要
目的探讨阿托伐他汀联合氯吡格雷治疗急性脑梗死的临床疗效及安全性。方法将80例急性脑梗死患者随机分为观察组和对照组,各40例,对照组予降压、脱水、抗血小板(100 mg阿司匹林)等常规治疗。观察组在此基础上予阿托伐他汀联合氯吡格雷治疗,两组均持续治疗3个月。治疗后对比分析两组的临床疗效及两组患者治疗前后血脂各项指标及炎症指标(hs-CRP、TNF-α)、NISS评分的变化情况,并对患者治疗期间的用药安全性进行观察。结果观察组患者治疗后的总有效率达92.5%,与对照组比较,差异有统计学意义(P<0.05)。观察组和对照组患者治疗后的NIHSS评分比较结果显示,观察组患者的NIHSS评分显著低于对照组,差异有统计学意义(P<0.05)。观察组和对照组患者治疗后的炎症因子hs-CRP、TNF-α水平比较结果显示,观察组患者的hs-CRP、TNF-α水平分别显著低于对照组,差异有统计学意义(P<0.05)。两组患者治疗后的TC、TG、LDL-C及HDL-C水平比较,观察组患者的TC、TG、LDL-C水平分别显著低于对照组,差异有统计学意义(P<0.05)。观察组患者的HDL-C水平高于对照组,差异有统计学意义(P<0.05)。两组患者治疗期间未见明显的不良反应,安全性良好。结论阿托伐他汀联合氯吡格雷治疗急性脑梗死的临床疗效确切,可以显著改善患者的神经功能,调节血脂,抑制炎症反应,安全性好,值得临床推广和应用。
Objective To explore the clinical efficacy and safety of atorvastatin combined with clopidogrel in the treatment of acute cerebral infarction.Methods Eighty patients with acute cerebral infarction were randomly divided into an observation group and a control group,with 40 cases in each group.The control group was given routine treatment such as antihypertensive,dehydration,and antiplatelet(100 mg aspirin)treatment.The observation group was treated with atorvastatin combined with clopidogrel on the above basis.Both groups were given continuing treatment for 3 months.After treatment,the clinical efficacy of the two groups,as well as the changes of blood lipid indexes and inflammation indexes(hs-CRP,TNF-α)and NISS scores before and after treatment in the two groups were analyzed.And the safety of medication during the treatment was observed.Results The total effective rate of patients in the observation group after treatment reached 92.5%,which was statistically significant from that of the control group(P<0.05).The NIHSS score of the observation group was significantly lower than that of the control group,and the difference was significant(P<0.05).The levels of hs-CRP and TNF-αin the observation group were significantly lower than those in the control group,and the differences were significant(P<0.05).The TC,TG,LDL-C levels of the observation group were significantly lower than those of the control group,and the differences were significant(P<0.05).The HDL-C level of the observation group was higher than that of the control group,and the difference was significant(P<0.05).No obvious adverse reactions were seen during the treatment in the two groups,and the safety was good.Conclusion Atorvastatin combined with clopidogrel in the treatment of acute cerebral infarction has definite clinical effect,which can significantly improve the patient’s nerve function,regulate blood lipids,inhibit inflammation,and has good safety.It is worthy of clinical promotion and application.
作者
张艳辉
冯禄
张策
ZHANG Yanhui;FENG Lu;ZHANG Ce(Department of Neurology,FushunCity Central Hospital of Liaoning Province,Fushun 113000,China;Department of General surgery,Fushun Central Hospital of Liaoning Province,Fushun113000,China;Department ofInternalMedicine,Xinfu District People's Hospital in Fushun City of Liaoning Province113000,China)
出处
《中国现代医生》
2020年第25期103-106,共4页
China Modern Doctor
关键词
急性脑梗死
阿托伐他汀
氯吡格雷
临床疗效
安全性
Acute cerebral infarction
Atorvastatin
Clopidogrel
Clinical efficacy
Safety
