摘要
目的探讨松龄血脉康胶囊联合常规治疗对高血压伴不稳定心绞痛患者的临床疗效。方法148例患者随机分为对照组和观察组,每组74例,对照组给予常规治疗(降血压、抗血小板聚集、β受体拮抗药),观察组在对照组基础上加用松龄血脉康胶囊,疗程12周。检测临床疗效、血压(24 h舒张压、24 h收缩压)、心功能指标(LVEF、SV)、血管内皮功能指标(ET、NO)、病情相关因子(Hcy、hs-CRP、SOD、GSH-Px)、主要不良心血管事件发生率变化。结果观察组总有效率高于对照组(P<0.05),主要不良心血管事件发生率更低(P<0.05)。治疗12周后,观察组心功能指标、NO高于对照组(P<0.05),血压、ET更低(P<0.05)。治疗6、12周后,观察组Hcy、hs-CRP低于对照组(P<0.05),SOD、GSH-Px更高(P<0.05)。结论松龄血脉康胶囊联合常规治疗可改善高血压伴不稳定心绞痛患者血管内皮功能和心功能,调节氧化应激、炎性反应等血清因子水平,降低预后不良发生。
AIM To explore the clinical effects of Songling Xuemaikang Capsules combined with conventional treatment on patients with hypertension and unstable angina.METHODS One hundred and forty-eight patients were randomly assigned into control group(74 cases)for 12-week intervention of conventional treatment(lowering pressure,anti-platelet aggregation,β-receptor antagonists),and observation group(74 cases)for 12-week intervention of both Songling Xuemaikang Capsules and conventional treatment.The changes in clinical efficacy,blood pressures(24 h diastolic pressure,24 h systolic pressure),cardiac function indices(LVEF,SV),vascular endothelial function indices(ET,NO),disease-related factors(Hcy,hs-CRP,SOD,GSH-Px)and incidence of major adverse cardiovascular events were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P<0.05),along with lower incidence of major adverse cardiovascular events(P<0.05).After 12-week treatment,the observation group displayed higher cardiac function indices and NO than the control group(P<0.05),along with lower blood pressures and ET(P<0.05).After 6-week and 12-week treatment,the observation group exhibited lower Hcy and hs-CRP(P<0.05),along with higher SOD and GSH-Px(P<0.05).CONCLUSION For the patients with hypertension and unstable angina,Songling Xuemaikang Capsules combined with conventional treatment can improve vascular endothelial functions and cardiac functions,regulate serum factor levels such as oxidative stress and inflammatory response,and reduce the occurrence of poor prognosis.
作者
张志敏
高淑梅
李金萍
侯瑞田
ZHANG Zhi-min;GAO Shu-mei;LI Jin-ping;HOU Rui-tian(Department of Cardiac Electrophysiology,The Hospital Affiliated to Chengde Medical University,Chengde 067000,China)
出处
《中成药》
CAS
CSCD
北大核心
2020年第10期2622-2626,共5页
Chinese Traditional Patent Medicine
基金
河北省中医药管理局科研计划项目(2016189)。
关键词
松龄血脉康胶囊
常规治疗
高血压
不稳定心绞痛
Songling Xuemaikang Capsules
conventional treatment
hypertension
unstable angina
