摘要
含Ⅰ型血小板结合蛋白基序的解聚蛋白样金属蛋白酶(ADAMTS)-4是蛋白酶家族的一员,参与心脑血管疾病的发生发展,最终导致临床缺血事件发生。该文综述ADAMTS-4与颈动脉及冠状动脉易损斑块关系的研究进展,以帮助了解ADAMTS-4在易损斑块中的作用,为易损斑块人群的疾病预防、诊断、个体化治疗提供依据。
A disintegrin-like and metalloproteinase with thrombospondin type l motifs(ADAMTS)-4 is a member of the protease family and is related to the occurrence and development of cardiovascular and cerebrovascular diseases,which ultimately leads to clinical ischemic events happen.The paper summarized the research progress on the correlation between ADAMTS-4 and vulnerable plaque in carotid and coronary arteries,so as to help understand the role of ADAMTS-4 played in vulnerable plaque,and to provide theory basis for the prevention,diagnosis and individualized treatment of vulnerable plaque.
作者
邓先明
陈光忠
Deng Xianming;Chen Guangzhong(Department of Neurosurgery,the Second School of Clinical Medicine,Southern Medical University,Guangzhou 510515,China;不详)
出处
《中国脑血管病杂志》
CAS
CSCD
北大核心
2020年第10期627-630,635,共5页
Chinese Journal of Cerebrovascular Diseases
