摘要
目的:调查分析老年患者存在的多重用药风险情况及影响因素。方法:采用问卷调查方式,调查本院多重用药管理门诊的老年患者多重用药情况,以Beers标准2019版为依据,对老年患者多重用药风险及影响因素进行分析。结果:共调查231例老年患者,其平均为(80.77±8.61)岁,平均用药种数(7.86±2.71)种,其中99例(42.9%)发生了至少1项用药风险,共涉及147例次。存在用药风险的药物主要为苯二氮艹卓类、质子泵抑制剂及阿司匹林、新型口服抗凝药等。就诊时告知医师目前使用的所有药物(OR=0.516,95%CI 0.285~0.936)是老年患者用药风险的"保护性因素",年龄(OR=2.147,95%CI 1.204~3.830)、合并用药种数(OR=2.095,95%CI 1.094~4.013)是用药风险的"危险因素"(P<0.05)。结论:老年患者多重用药风险发生率较高,高龄及合并用药种数≥10种是发生用药风险的危险人群,沟通不足是用药风险的危险因素,应识别高危人群,采取适当的措施以预防和减少老年患者潜在不适当用药,降低用药风险,提高其用药合理性。
Objective:To analyze the prevalence and risk factors of polymedication among elderly outpatients.Methods:Elderly polymedication outpatients were recruited for a questionnaire survey.The Beers Criteria(Version 2019)was applied to analyze the prevalence and risk factors of potentially inappropriate medication(PIM)in elderly patients.Results:The average age of the 231 enrolled outpatients was(80.77±8.61)years,for each patient,(7.86±2.71)kinds of medicines were being used.Among the surveyed subjects,99(42.9%)had at least 1 medication risk,which were 147 in total.The drugs at risk of use were mainly benzodiazepines,proton pump inhibitors,aspirin and new oral anticoagulants.Reporting all present medications(OR=0.516,95%CI 0.285-0.936)was a protecting factor of medication.Age(OR=2.147,95%CI 1.204-3.830)and number of combined drugs(OR=2.095,95%CI 1.094-4.013)were risk factors of medication.Conclusion:The incidence of PIM is high among the elderly patients,age,number of prescribed drugs and poor communication are risk factors of medication.It is necessary to take appropriate measures to identify and prevent potential inappropriate drug use and further improve the rationality of drug use in elderly patients.
作者
曲国红
智俊娜
陈龙保
王振山
王怡
谈震
QU Guohong;ZHI Junna;CHEN Longbao;WANG Zhenshan;WANG Yi;TAN Zhen(Department of Pharmacy,Geriatric Hospital of Nanjing Medical University/Jiangsu Province Official Hospital,Nanjing 210024)
出处
《药学与临床研究》
2020年第5期363-366,共4页
Pharmaceutical and Clinical Research
基金
江苏省药学会(A201710)
南京市药学会(2017YX016)。
