摘要
目的探讨前列地尔联合阿托伐他汀对2型糖尿病合并脑梗死患者颈动脉粥样硬化斑块及血液流变学的影响。方法将110例2型糖尿病合并脑梗死患者随机分为对照组和观察组,各55例。对照组采用阿托伐他汀治疗,观察组在对照组基础上联合前列地尔治疗,比较两组的疗效。结果治疗后,观察组血脂指标水平优于对照组,颈动脉斑块面积、IMT小于对照组(P<0.05)。治疗后,两组血液流变学指标均改善,且观察组优于对照组(P<0.05)。观察组治疗总有效率高于对照组(P<0.05)。结论前列地尔联合阿托伐他汀能有效改善2型糖尿病合并脑梗死患者的血脂水平以及血液流变学指标,减小颈动脉斑块面积和IMT,效果显著。
Objective To investigate the effects of alprostadil combined with atorvastatin on carotid atherosclerotic plaque and hemorheology in patients with type 2 diabetes mellitus complicated with cerebral infarction.Methods A total of 110 patients with type 2 diabetes mellitus complicated with cerebral infarction were randomly divided into control group and observation group,with 55 cases in each group.The control group was treated with atorvastatin,the observation group was treated with alprostadil on the basis of the control group,and the efficacy of the two groups was compared.Results After treatment,the blood lipid indexes levels of the observation group were better than those of the control group,and the area of carotid plaque and IMT were smaller than those of the control group(P<0.05).After treatment,hemorheology indexes of both groups improved,and those in the observation group were better than the control group(P<0.05).The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).Conclusion Alprostadil combined with atorvastatin can effectively improve blood lipid levels and hemorheology indexes in patients with type 2 diabetes mellitus complicated with cerebral infarction,and reduce the area of carotid plaque and IMT,with significant effects.
作者
王小妮
王雪红
郭爱红
WANG Xiaoni;WANG Xuehong;GUO Aihong(Lantian County People's Hospital,Xi'an 710500;Xianyang Hospital of Yan'an University,Xianyang 712000,China)
出处
《临床医学研究与实践》
2020年第30期23-25,共3页
Clinical Research and Practice
基金
陕西省重点研发计划项目(No.2017SF-282)。
关键词
前列地尔
阿托伐他汀
2型糖尿病
脑梗死
颈动脉粥样硬化斑块
alprostadil
atorvastatin
type 2 diabetes mellitus
cerebral infarction
carotid atherosclerotic plaque
