摘要
目的探讨磷酸化tau蛋白(P-tau)及其与总tau蛋白(P-tau/T-tau)比对预测创伤性脑损伤(traumatic brain injury,TBI)病人6个月内死亡和预后情况的诊断效能。方法2017年6月~2019年6月收治的TBI病人90例。采用格拉斯哥预后评分(GOS)记录病人随访6个月后死亡和预后情况,由此将病人分为死亡组、存活组、预后良好组、预后不良组,采用Logistic回归分析死亡相关因素,分析伤后6小时内P-tau、P-tau/T-tau与GOS评分相关性,绘制ROC曲线评估前二者对死亡和预后的预测效能。结果最终纳入86例,死亡组发病至入院时间、P-tau、P-tau/T-tau均高于存活组,格拉斯哥昏迷评分(GCS)低于存活组,差异有统计学意义(P<0.05);P-tau和P-tau/T-tau为死亡危险因素(P<0.05);预后良好组GOS评分高于预后不良组,P-tau和P-tau/T-tau低于预后不良组,差异有统计学意义(P<0.05);P-tau和P-tau/T-tau均与GOS评分呈负相关(r=-0.773、-0.745,均P=0.000);P-tau和P-tau/T-tau预测病人死亡的AUC分别为0.767与0.873、0.968与0.961,两者预测死亡(91.30%和91.34%)和预后(94.11%和91.24%)的敏感性无明显差异(P>0.05)。结论P-tau水平和P-tau/T-tau值可有效预测TBI病人6个月内死亡和预后情况。
Objective To explore the diagnostic efficiency of phospho-tau(P-tau)and phospho tau-total tau radio(P-tau/T-tau)for predicting death and prognosis situation within half a year in traumatic brain injury(TBI)patients.Methods 90 TBI patients treated in our hospital from June 2017 to June 2019 were employed as research targets.Patients’death situation and prognosis by Glasgow outcome score(GOS)in half a year of follow-up were recorded and thus all patients were divided into death group,survival group,good prognosis group and bad prognosis group.Using Logistic regression to analyse the related factors of death,analysing relation among P-tau,P-tau/T-tau within 6 h of injury and GOS scores,constructing ROC curve to assess prediction efficiency of P-tau and P-tau/T-tauon TBI patients’death and prognosis.Results There were 86 cases were employed.The duration from onset of symptoms to admission,P-tau and P-tau/T-tauin the death group were higher than those in the survival group(P<0.05);Both of P-tau and P-tau/T-tau were the risk factors of death(P<0.05);GOS score in good prognosis group was higher than that bad prognosis group,P-tau and P-tau/T-tau in good prognosis group were lower than that bad prognosis group(P<0.05);P-tau and P-tau/T-tau were negatively correlated with GOS score(r=-0.773、-0.745,all P=0.000);The AUC of P-tau and P-tau/T-tauto predict patients’death and prognosis were 0.767 and 0.873,0.968 and 0.961,respectively.There were no significant difference respectively between both of them in sensitivity of predicting death(91.30%and 91.34%)and prognosis(94.11%and 91.24%,P>0.05).Conclusion P-tau and P-tau/T-tau can effectively predict TBI patients’death situation and prognosis within half a year.
作者
夏承东
桂明
韩飞
杜向阳
黄大可
XIA Chengdong;GUI Ming;HAN Fei(Department of Neumsurgery,Lu'an Hospital of Traditional Chinese Medicine,Anhui,237006,China)
出处
《临床外科杂志》
2020年第8期756-759,共4页
Journal of Clinical Surgery
