摘要
目的观察加味桂枝汤治疗寒冷型荨麻疹风寒束表证的临床疗效和安全性。方法60例寒冷型荨麻疹风寒束表证患者随机分为治疗组和对照组各30例。治疗组采用加味桂枝汤治疗,每日1剂。对照组采用口服盐酸西替利嗪片治疗,每次10mg,每日1次。两组均治疗28天。分别于治疗前及治疗7、14、28天时对患者瘙痒程度、风团数目、风团直径、持续时间、发作频率进行评分,并判定临床疗效。结果治疗组及对照组治疗愈显率分别为96.67%和80.00%,两组比较差异无统计学意义(P>0.05)。与本组治疗前比较,两组瘙痒程度、风团数目、风团直径、持续时间在治疗7天、14天、28天时均降低(P<0.05);发作频率治疗组在治疗7天、14天、28天时,对照组在治疗14天、28天时降低(P<0.05)。治疗14天时治疗组瘙痒程度、风团数目、发作持续时间、发作频率,对照组瘙痒程度、风团直径、持续时间、发作频率,比治疗7天时降低(P<0.05);治疗28天时治疗组瘙痒、风团直径,对照组发作频率,比治疗14天时降低(P<0.05)。与对照组同时间比较,治疗组治疗7天时风团直径、持续时间、发作频率,14天时瘙痒程度、风团数目、发作频率,28天时瘙痒程度、风团数目、风团直径、持续时间、发作频率的差异均有统计学意义(P<0.05)。结论加味桂枝汤可安全有效治疗寒冷型荨麻疹风寒束表证,改善临床症状。
Objective To observe the clinical effect and safety of modified Guizhi Decoction(桂枝汤)on cold type urticaria of superficies tightened by wind-cold.Methods A total of 60 cases of patients with cold type urticaria of superficies tightened by wind-cold were randomly divided into a treatment group and a control group,with 30 cases in each group.The treatment group received modified Guizhi Decoction for treatment,one dose per day,while the control group was orally given cetirizine hydrochloride tablets,10 mg each time,once a day.Both groups were treated for 28 days.Before treatment and on the 7 th,14 th,and 28 th day of treatment,patients were scored on the degree of itching,number of wheal,diameter of wheal,duration,and frequency of attacks,and the clinical efficacy was determined.Results The markedly effective rate was 96.67%in the treatment group and 80.00%in the control group,and the difference was not statistically significant(P>0.05).Compared within group before treatment,the degree of pruritus,the number of wheal,the diameter of wheal,and the duration of both groups were reduced on the 7 th,14 th,and 28 th day of treatment(P<0.05).Frequency of attacks was reduced on the 7 th,14 th and 28 th day in the treatment group and on the 14 th and 28 th day in the control group(P<0.05).The degree of pruritus,the number of wheal,the duration of attacks,and the frequency of attacks in the treatment group on the 14 th day were lower than those on the 7 th day(P<0.05);while the degree of pruritus,diameter of wheal,duration and frequency of attacks on the 14 th day were lower than those on the 7 th day(P<0.05).On the 28 th day,degree of pruritus,diameter of wheal in the treatment group,frequency of attacks in the control group was lower than those on the 14 th day(P<0.05).Compared with the control group at the same time,the differences were statistically significant in wheal diameter,duration,attack frequency on the 7 th day,degree of pruritus,the number of wheal,attack frequency on the 14 th day,and itching degree,the n
作者
吴敏
郭静
张虹亚
刘涛峰
刘小平
孙洪波
王建锋
曹宇
章纬
WU Min;GUO Jing;ZHANG Hongya;LIU Taofeng;LIU Xiaoping;SUN Hongbo;WANG Jianfeng;CAO Yu;ZHANG Wei(The First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei,230031;Affiliated Hospital of Chengdu University of Chinese Medicine)
出处
《中医杂志》
CSCD
北大核心
2020年第19期1717-1720,共4页
Journal of Traditional Chinese Medicine
关键词
荨麻疹
加味桂枝汤
风寒束表证
风团
urticaria
modified Guizhi Decoction(桂枝汤)
syndrome of superficies tightened by wind-cold
wheal
