摘要
目的了解新疆乌鲁木齐市(简称乌市)男男性行为者(MSM)中人乳头瘤病毒(HPV)的感染状况及影响因素。方法采用滚雪球的方法招募MSM 783名,采集肛门脱落细胞分析HPV感染率,使用Logistic回归模型分析HPV感染相关的影响因素。结果HPV任一型别、2种以上型别、高危型和低危型感染率分别为47.38%、22.86%、35.76%和11.62%。2价、4价和9价疫苗型别感染率分别为3.83%、9.96%和16.99%。近6个月发生过肛交性行为[比值比(OR)=4.46,95%可信区间(CI):1.19~16.70]、肛交性行为方式以被插入为主(OR=1.81,95%CI:1.28~2.55)、毒品使用史(OR=2.09,95%CI:1.46~2.97)是任一型别的危险因素,接受自愿咨询检测(OR=0.42,95%CI:0.20~0.91)是其保护因素。肛交性行为方式以被插入为主(OR=1.91,95%CI:1.29~2.84)、毒品使用史(OR=2.20,95%CI:1.47~3.28)可增加2种以上型别感染的风险,自愿咨询检测史(OR=0.42,95%CI:0.20~0.90)可降低其感染风险。近6个月发生过肛交性行为(OR=9.74,95%CI:1.19~19.77)、肛交性行为方式被插入为主(OR=1.95,95%CI:1.37~2.78)、毒品使用史(OR=1.87,95%CI:1.30~2.68)的MSM感染高危型别的HPV风险较高。结论新疆乌市MSM的肛门HPV任一型别、≥2种和高危型HPV感染率较高。应对该人群采用筛查、定期随访和自愿咨询检测等有效干预措施,降低HPV的传播率。
Objective To investigate the prevalence and predictors of anal detectable human papillomavirus(HPV)infection among men who have sex with men(MSM)in Urumqi,Xinjiang.Methods 783 MSM were recruited by snowball sampling.Anal exfoliated cells were collected to analyze the prevalence of HPV.Predictors of any anal HPV infection was analyzed by logistic regression.Results The genotyping results of anal HPV infection were available among 783 MSM.Of them,371 cases(47.38%)were positive for at least one of the targeted 37 HPV genotypes,179 cases(22.86%)for 2 types or above,280 cases(35.76%)for high-risk HPV genotypes,and 91(11.62%)for any low-risk HPV genotypes.The infection rates of 2-valent,4-valent and 9-valent vaccine types were 30(3.83%),78(9.96%)and 133(16.99%)respectively.The risk factors of any anal HPV infection included anal sex in the past six months(OR=4.46,95%CI:1.19-16.70),receptive anal intercourse in the past year(OR=1.81,95%CI:1.28-2.55),and history of drug abuse(OR=2.09,95%CI:1.46-2.97),and acceptance of voluntary counseling and testing services in the past year(OR=0.42,95%CI:0.20-0.91)was protective factor.Anal sex(OR=1.91,95%CI:1.29-2.84),history of drug abuse(OR=2.20,95%CI:1.47-3.28)and voluntary counseling and testing(OR=0.42,95%CI:0.20-0.90)were predictors of 2 types or above anal HPV infection.Experience in anal intercourse in the past six months(OR=9.74,95%CI:1.19-19.77),receptive anal intercourse in the past year(OR=1.95,95%CI:1.37-2.78)and history of drug abuse(OR=1.87,95%CI:1.30-2.68)were predictors of high-risk HPV infection.Conclusion HPV prevalence is high among MSM in Urumqi,Xinjiang including any anal HPV infection,2 types or above HPV infection and high-risk HPV infection.Effective intervention should be promoted such as screening,regular follow-up,and voluntary counselling and testing to reduce HPVspreading among MSM.
作者
刘礼荣
陈珍
张国珍
田恬
王璐
张泽文
戴江红
LIU Lirong;CHEN Zhen;ZHANG Guozhen;TIAN Tian;WANG Lu;ZHANG Zewen;DAI Jianghong(School of Public Health,Xinjiang Medical University,Urumqi 830011,China)
出处
《中国艾滋病性病》
CAS
CSCD
北大核心
2020年第9期977-981,共5页
Chinese Journal of Aids & STD
基金
国家自然科学基金(81560539,81860590)。
