摘要
以聚乳酸(PLA)、聚羟基乙酸(PGA)为原料,通过静电纺丝制备了不同复合比的PLA/PGA纳米纤维膜,并对其进行体外降解实验;通过细胞毒性、体外降解质量损失率和拉伸强度损失率等测试,考察了PGA含量对纳米纤维膜的生物相容性和降解性能的影响。结果表明:在PGA质量分数为10%~40%条件下,PGA含量越高,PLA/PGA纳米纤维膜的细胞毒性越低、黏附细胞生长状态越好,相比纯PLA纳米纤维膜表现出更好的生物相容性;相对于纯PLA纳米纤维膜,体外降解过程中PLA/PGA纳米纤维膜的质量损失更大,且PGA含量越高,降解初期质量损失速率越快,但降解后期质量损失速率明显变慢;加入PGA后的PLA/PGA纳米纤维膜的拉伸强度低于纯PLA纳米纤维膜,其降解过程中的拉伸强度损失率虽然随PGA含量的增加而增大,但均小于纯PLA纳米纤维膜;体外降解30 d后,PGA质量分数为40%的PLA/PGA纳米纤维膜的拉伸强度损失率为51.7%,而纯PLA纳米纤维膜的拉伸强度损失率达60.0%。
Polylactic acid/polyglycolic acid(PLA/PGA)nanofiber membranes were prepared at different composite ratio by electrospinning process.The degradation experiment of the nanofiber membrane was carried out in vitro.The effects of PGA content on the biocompatibility and degradation properties of the nanofiber membrane were investigated by testing its cytotoxicity,degradation mass loss rate in vitro and tensile strength loss rate.The result showed that the higher the content of PGA in the range of 10%-40%,the lower the cytotoxicity of PLA/PGA nanofiber membrane and the better the growth state of adherent cells,and PLA/PGA nanofiber membrane showed better biocompatibility than pure PLA nanofiber membrane;PLA/PGA nanofiber membrane showed more mass loss than pure PLA nanofiber membrane,and the higher the PGA content was,the higher the mass loss rate was at the initial stage of degradation,but the mass loss rate became slow at the later stage of degradation;the tensile strength of PLA/PGA nanofiber membrane after adding PGA was lower than that of pure PLA nanofiber membrane,and the tensile strength loss rate increased with the increase of PGA content,but was still lower than that of pure PLA nanofiber membrane during degradation;and the tensile strength loss rate of PLA/PGA nanofiber membrane with 40%PGA by mass fraction was 51.7%after 30 days of degradation in vitro while that of pure PLA nanofiber membrane was 60.0%.
作者
王诗卉
李光
金俊弘
杨胜林
WANG Shihui;LI Guang;JIN Junhong;YANG Shenglin(State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,College of Materials Science and Engineering,Donghua University,Shanghai 201620)
出处
《合成纤维工业》
CAS
2020年第5期33-38,共6页
China Synthetic Fiber Industry
关键词
聚乳酸纤维
聚羟基乙酸纤维
复合纤维
静电纺丝
降解性能
生物相容性
polylactic acid fiber
polyglycolic acid fiber
composite fiber
electrospinning
degradation
biocompatibility
