摘要
目的:评价杭州地区普通型、重型2019冠状病毒病(COVID-19)中西医结合治疗的临床疗效。方法:68例确诊COVID-19患者来源于2020年1月20日至2月29日杭州市西溪医院,在抗病毒、吸氧、抗炎等治疗基础上,接受中医药治疗的51例为中西医组,其余17例为西医组。观察并比较两组症状积分,体温复常、影像改善、核酸转阴时间,住院天数及不良反应。结果:最常见症状为咳嗽72.06%(49/68)、发热69.12%(47/68)、乏力60.29%(41/68)。治疗后两组症状积分较治疗前均有改善(P<0.05);咳嗽、乏力症状积分中西医组改善优于西医组(P<0.05)。中西医组核酸转阴、影像改善时间较西医组缩短(P<0.05)。抗病毒药物不良反应:腹泻(2级以上)中西医组明显少于西医组(19.61%vs 52.94%,P<0.05)。老年、合并基础疾病患者影像改善时间延长(P<0.05),使用激素(>3d)患者影像改善、核酸转阴时间延长(P<0.05)。结论:中西医结合治疗与纯西医治疗相比具有同等疗效,在改善咳嗽、乏力症状上具有优势;能缩短核酸转阴和影像改善时间;能减轻腹泻等不良反应。老年、合并基础疾病可能延缓病灶吸收;激素可能延缓核酸转阴、病灶吸收,应当进一步掌握使用指征。
Objective:To evaluate the clinical efficacy of integrated traditional and western medicine for common and severe Corona Virus Disease 2019(COVID-19)in Hangzhou area.Methods:A total of 68 patients with COVID-19 from Jannary 20,2020 to February 29,2020 in Xixi Hospital of Hangzhou were divided into western medicine group(WM group)(17 cases)or traditional Chinese and western medicine group(TCM group)(51 cases)according to different treatments.The WM group received symptomatic supportive treatment such as antiviral,oxygen inhalation,and anti-inflammatory.The TCM group added TCM therapy.To observe and compare clinical efficacy indicators of two groups,such as symptom scores,normal body temperature,image improvement,hospitalization,negative nucleic acid test,and adverse reactions.Results:The main complaints were cough(72.06%,49/68),fever(69.12%,47/68),and fatigue(60.29%,41/68).Symptoms improved in both groups after treatment(P<0.05).The improvement of cough and fatigue symptoms scores in TCM group was better than that in WM group(P<0.05).Compared with the WM group,the time of negative nucleic acid test and image improvement were significantly shortened in TCM group(P<0.05).The incidence of diarrhea(grade 2 or higher)in TCM group was significantly lower than that in WM group(19.61%vs 52.94%,P<0.05).Longer image improvement time in elderly or patients with underlying diseases(P<0.05),and longer image improvement and negative nucleic acid test time in patients with hormones(>3 d)(P<0.05).Conclusion:Compared with pure western medicine treatment,integrated traditional Chinese and western medicine treatment has the same curative effect,and it has advantages in improving cough and fatigue symptoms;it can shorten the time for nucleic acid to turn negative and image improvement;it can reduce adverse reactions such as diarrhea.Old age,combined with underlying diseases may delay the absorption of the focus.Hormones may delay the transfer of nucleic acids to the negative and the absorption of lesions,and the instructions for use s
作者
林泽晨
喻剑华
肖存书
荀运浩
蔡兆斌
黄劲松
林胜友
LIN Ze-chen;YU Jian-hua;XIAO Cun-shu;XUN Yun-hao;CAI Zhao-bin;HUANG Jin-song;LIN Sheng-you(Hangzhou Hospital of Traditional Chinese Medicine,Hangzhou 310007,China;Xixi Hospital of Hangzhou,Hangzhou 310023,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2020年第8期4222-4225,共4页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
2020年杭州市新型冠状病毒感染的肺炎防治科研攻关项目(第一批)(No.20202013A01)。
关键词
2019冠状病毒病
中西医结合
临床疗效
传染病
瘟疫
不良反应
预后
糖皮质激素
Corona Virus Disease 2019(COVID-19)
Integrated traditional Chinese and western medicine
Clinical efficacy
Infectious disease
Plague
Adverse reaction
Prognosis
Glucocorticoid
