摘要
背景:目前对抑郁症的诊断和研究缺乏客观的生物学指标,功能性近红外光谱作为一种新兴无创的脑功能成像技术,可能是抑郁症识别和辅助诊断的潜在生物标记物。目的:综述功能性近红外光谱技术在抑郁症研究中的相关应用,为临床研究提供指导。方法:以“functional near-infrared spectroscopy,oxyhemoglobins,prefrontal cortex,depressive Disorder”为英文检索词,以“功能性近红外光谱,氧合血红蛋白,前额叶皮层,抑郁症”为中文检索词,由第一作者检索中国知网、万方、维普、PubMed和Web of Science数据库1996至2020年发表的文献,经过筛选最终获得50篇文献进行综述。结果与结论:功能性近红外光谱信号可能是抑郁症潜在的生物标记物。功能性近红外光谱技术主要从额叶的血流动力学变化方面进行抑郁症的认知功能障碍研究,可用于抑郁症的鉴别诊断。但是目前对于功能性近红外光谱的研究还处于探索阶段,还存在一些缺陷,可以增加研究样本量和监测指标,同时将功能性近红外光谱与其他技术相融合,提高时间和空间分辨率,更加系统、全面、准确地研究抑郁症的神经机制。
BACKGROUND:The current diagnosis and study of depression lacks objective biological indicators.As an emerging non-invasive brain functional imaging technology,functional near infrared spectroscopy(fNIRS)may be a potential biomarker for the identification and diagnosis of depression.OBJECTIVE:To review the application of fNIRS technique in depression research and provide guidance for clinical research.METHODS:The keywords were“functional near-infrared spectroscopy,oxyhemoglobins,prefrontal cortex,depressive disorder.”The first author searched CNKI,WanFang,VIP,PuMed and Web of Science database from 1996 to 2020 in Chinese and English.Finally,50 literatures were selected for review.RESULTS AND CONCLUSION:fNIRS signal may be a potential biomarker for depression.fNIRS technology is mainly used to study the cognitive dysfunction of depression based on the frontal lobe hemodynamic changes,which can be used for the differential diagnosis of depression.However,the current research on fNIRS is still in the exploratory stage,and there are still some defects in the existing research,which need to be further optimized and deepened in the future research.It can increase the study sample size and monitoring indicators,and integrate fNIRS with other technologies to improve the temporal and spatial resolution,so as to study the neural mechanism of depression systematically,comprehensively and accurately.
作者
王丽群
李雨谿
金荣疆
王文春
庞日朝
张安仁
Wang Liqun;Li Yuxi;Jin Rongjiang;Wang Wenchun;Pang Richao;Zhang Anren(College of Health and Rehabilitation,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,Sichuan Province,China;Department of Rehabilitation Medicine,General Hospital of Western Theater Command,Chengdu 610083,Sichuan Province,China)
出处
《中国组织工程研究》
CAS
北大核心
2021年第11期1799-1804,共6页
Chinese Journal of Tissue Engineering Research
基金
国家重点研发计划中医药现代重点研发计划(2019YFC1710302),项目负责人:金荣疆。
关键词
功能性近红外光谱
氧合血红蛋白
前额叶皮质
抑郁症
脑
综述
functional near-infrared spectroscopy
oxyhemoglobins
prefrontal cortex
depressive disorder
brain
review
