摘要
目的:探究桃红四物汤治疗口腔黏膜下纤维性变(OSF)的作用网络和分子作用机制。方法:基于网络药理学的方法,结合多个数据库分析桃红四物汤的有效成分和其治疗OSF的作用靶点。通过Cytoscape和R软件构建作用网络和进行生物信息学分析。结果:得到桃红四物汤治疗OSF的作用靶点42个;槲皮素(quercetin)、山柰酚(kaempferol)、阿魏酸(ferulic acid)、芍药苷(paeoniflorin)、木犀草素(luteolin)、黄芩素(baicalein)可能是桃红四物汤治疗OSF的主要活性成分;其作用于JUN、HMOX1、MAPK家族、MMP家族等靶点,参与细胞因子活性、细胞因子受体结合、生长因子活性和DNA结合转录激活活性等生物过程,通过HIF-1信号通路、NF-κB信号通路、MAPK信号通路、Wnt信号通路和TGF-β信号通路等共同发挥治疗OSF的作用。结论:桃红四物汤中多成分通过多靶点、多通路治疗OSF。
Objective: To explore the molecular mechanism of Taohong Siwu decoction in the treatment of oral submucous fibrosis(OSF). Methods: Using the method of network pharmacology, multiple databases were used to analyze the targets of Taohong Siwu decoction and oral submucous fibrosis. Cytoscape and R software was used to screen targets and analyze their gene functions and signaling pathways. Results: 42 therapeutic targets of Taohong Siwu Decoction on OSF were obtained. Quercetin, kaempferol, ferulic acid, paeoniflorin, luteolin and baicalein may be the main active components of Taohong Siwu Decoction in the treatment of OSF. These active components act on JUN, HMOX1, MAPK family, MMP family and other targets, participate in cytokine activity, cytokine receptor binding, growth factor activity and DNA binding transcriptional activation activity and other biological processes, through HIF-1 signal pathways, NF-κ B signaling pathway, MAPK signaling pathway, Wnt signaling pathway and TGF-β signaling pathway, play a role in the treatment of OSF. Conclusion:The multiple components in Taohong Siwu decoction treated OSF by multi-target and multi-pathway.
作者
朱可可
周蓉
陈明
王志豪
王宗康
谭劲
ZHU Ke-ke;ZHOU Rong;CHEN Ming;WANG Zhi-hao;WANG Zong-kang;TAN Jin(The First Affiliated Hospital of Hunan University of Chinese Medicine,Changsha Hunan 410007,China;Changsha Maternal and Child Health Care Hospital,Changsha Hunan 410008,China)
出处
《中医药导报》
2020年第13期129-133,共5页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
国家自然科学基金项目(81874496)
湖南中医药大学口腔医学一级学科开放基金重点项目(2019KQYY01)。
关键词
桃红四物汤
口腔黏膜下纤维性变
网络药理学
靶点
通路
Taohong Siwu decoction
oral submucous fibrosis
network pharmacology
taggets
pathways
