摘要
目的对比中成药镇痛活络酊和非甾体抗炎药(Nonsteroidal Anti-inflammatory Drugs,NSAIDs)治疗肱骨外上髁炎(lateral epicondylitis,LE)的短期临床疗效差异。方法筛选后符合纳入标准的LE患者60例,随机分为镇痛活络酊组(n=30)和NSAIDs组(n=30)。镇痛活络酊组外用镇痛活络酊,NSAIDs组外用法斯通凝胶(酮洛芬),两组均连续用药3周,3次/d。用药后3周、6周和12周连续随访,主要观测指标包括视觉模拟评分(visual analog scale,VAS);肩、肘和手的功能评分(Disabilities of the arm,Shoulder And Hand,DASH);无痛握力(Pain-free grip strength,PFGS)。VAS评分分别测量患者1周前用力活动时的VAS评分和正常休息时的VAS评分,记为VAS(活动时)和VAS(休息时)。运用统计学方法对比分析两组患者在VAS评分(活动时)、VAS评分(休息时)、DASH评分和PFGS上的差异。结果两组患者在VAS评分(活动时)、VAS评分(休息时)和DASH评分上均未见组间差异(P>0.05)。两组患者在用药前、用药后3周、用药后6周的PGFS对比同样无组间差异(P=0.91,P=0.42,P=0.13)。但是,在用药后12周,镇痛活络酊组的PFGS高于NSAIDs组(P=0.02)。结论镇痛活络酊缓解LE疼痛的效果与外用NSAIDs相当,对提升伸肌力效果则更优。
Objective To compare the short-term clinical effects difference between analgesic tincture and topical nonsteroidal anti-inflammatory drugs(NSAIDs)in the treatment of lateral epicondylitis(LE).Methods 60 cases of LE patients were randomly divided into an analgesic tincture group(n=30)and a NSAIDs group(n=30).Analgesic tincture was chosen for the analgesic tincture group and topical ketoprofen gel for the NSAIDs group to treat LE.Two groups were treated continuously for 3w,3 times/day.Clinical results of each drug were followed-up at the time point of 3w,6w and 12w after usage.Observational indexes included the visual analogue scale(VAS),disabilities of the arm,shoulder and hand questionnaire(DASH)and pain-free grip strength(PFGS).The inter-group difference of VAS(at activity),VAS(at rest),DASH score and PFGS were compared subsequently.Results No difference of the VAS(at activity),VAS(at rest),DASH score were ascertained(P>0.05)between groups.Inter-group difference of PGFS was also not discerned at the time points of pre-treatment and 3 weeks and 6 weeks(P=0.91,P=0.42,P=0.13)post-treatment.However,PFGS of the analgesic tincture group was found to be higher than that of the NSAIDs group(P=0.02)after 12 weeks post-treatment.Conclusion Effect of analgesic tincture in releasing pain is almost the same to that of tropical NSAIDs,but a better effect in improving muscle strength.
作者
贾梦岩
肖军
JIA Mengyan;XIAO Jun(Department of Orthopaedic Surgery,Guangzhou First People's Hospital,Guangzhou 510180,China;Department of Orthopaedics,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China)
出处
《广州医药》
2020年第5期123-129,共7页
Guangzhou Medical Journal
