摘要
MicroRNAs(miRNAs)为真核生物中具有组织特异性和高度保守性的一类非编码调控的单链RNAs,长度约为20~24个核苷酸,其通过与靶标mRNA完全或不完全互补配对导致mRNA降解或抑制转录后翻译从而导致基因的沉默。随着研究的不断深入,证实miRNAs的异常表达与乳腺癌之间存在很大的相关性。miRNAs在肿瘤的产生、分化、侵袭以及转移等过程中都发挥着促进或抑制的作用。本文对近年来与乳腺癌相关的miRNAs及其作用机制的研究进行分析和展望,以期可以利用特异的miRNAs作为乳腺癌的早期诊断、预后指标和治疗的靶向目标。
MicroRNAs(miRNAs)are a group of non-coding single-stranded RNAs,which are composed of 20~24 nucleotides.In eukaryotes,miRNAs are highly conservative and tissue-specific.miRNAs usually induce mRNA degradation or post-transcriptional inhibition by completely or incompletely complementary pairing with their target mRNAs,leading to target gene silencing.Recent studies have confirmed that the dysregulation of miRNA expression is associated with breast cancer development.miRNAs play an important role in tumor formation,differentiation,invasion and metastasis.Recent studies on the expression,function and underlying mechanisms of specific miRNAs in breast cancer pathogenesis are discussed.The results presented here will provide solid evidences for the development of novel effective diagnosis,prognosis and treatment for breast cancer.
作者
佘为为
黄清荣
李延敏
张桂春
周菊华
SHE Weiwei;HUANG Qingrong;LI Yanmin;ZHANG Guichun;ZHOU Juhua(Institute for Tumor Immunology,School of Life Sciences,Ludong University,Yantai 264039,China;Shanghai Vocational College of Agriculture and Forestry,Shanghai 201699,China)
出处
《鲁东大学学报（自然科学版）》
2020年第4期338-352,共15页
Journal of Ludong University:Natural Science Edition
基金
山东省自然科学基金资助项目(ZR2018MH019)
山东省“泰山学者”建设工程专项(#tshw20120718)。
关键词
MIRNA
乳腺癌
作用机制
诊断
治疗
microRNAs
breast cancer
mechanism of action
diagnosis
therapy
