摘要
目的探讨利拉鲁肽对2型糖尿病肥胖患者核苷酸结合寡聚化结构域(NOD)样受体家族3(NLRP3)炎症小体、白细胞介素1β(IL-1β)、白细胞介素18(IL-18)及稳态模型胰岛素抵抗指数(HOMA-IR)、胰岛β细胞功能指数(HOMA-β)的影响。方法选取2型糖尿病肥胖患者44例,按随机数字表法分为观察组和对照组各22例,对照组给予口服二甲双胍降糖方案,观察组在对照组基础上给予利拉鲁肽降糖方案。分析两组治疗前和治疗后空腹胰高血糖素、C肽、空腹血糖、HbA1c、总胆固醇水平、NLRP3 mRNA、IL-1β、IL-18及HOMA-IR、HOMA-β的变化。结果治疗前两组各指标均没有显著性差异。治疗后观察组患者BMI、空腹血糖、餐后2小时血糖及HbA1c均显著降低,且显著低于对照组;30min、60minC肽及AUC-C肽显著增大,30min、60min、120min胰高血糖素及AUC-胰高血糖素显著下降;两组NLRP3 mRNA、IL-1β、IL-18均显著性降低,且观察组显著低于对照组;两组患者HOMA-IR均显著性降低,且观察组HOMA-IR显著低于对照组,而HOMA-β均显著性升高,且观察组HOMA-β显著高于对照组。结论利拉鲁肽可以抑制NLRP3激活减小IL-1β、IL-18炎症因子的释放,改善胰岛β细胞功能。
Objective To evaluate effects of liraglutide on NLRP3 inflammasome,IL-1β,IL-18,homeostasis model insulin resistance index(HOMA-IR)and homeostasis model assessment-βin obese type 2 diabetic patients(T2 DM).Methods A total of 44 T2 DM patients were divided into observation group(n=22)and control group(n=22)by random digital table.Control group was given melbine.Observation group was additionally given Liraglutide on the basis of control group.Before and after treatment,glucagon,C-peptide,blood glucose,HbA1 c,total cholesterol,NLRP3 mRNA,IL-1β,IL-18,HOMA-IR and HOMA-βwere analyzed.Results There was no significant difference in every measurements between two groups.After treatment,the levels of glucagon,C-peptide,blood glucose and HbA1 c were significantly decreased in observation group and lower than those in the control group.C-petide level at 30-,60-minutes after standard meals and its area under the curve(AUC)significantly increased.Glucagon concentration at 30-,60-and 120-minutes after standard meals and its AUC were significantly lower than that before liraglutide therapy.NLRP3 mRNA,IL-1βand IL-1 were significantly decreased in both groups.HOMA-IR in the observation group was significantly lower than that in the control group,while HOMA-IR was significantly lower than that in the control group.HOMA-βwas significantly higher,and HOMA-βin the observation group was significantly higher than that in the control group.Conclusion Liraglutide could reduce the level of NLRP3 and downstream proinflammatory cytokine,and improve the function of islet beta cells.
作者
彭玉凤
柴芳
周祥富
冯建燕
PENG Yufeng;CHAI Fang;ZHOU Xiangfu;Feng Jianyan(Pharmaceutical Department,Sanya People's Hospital,Sanya 572000,Hainan,China;Department of Pharmaceutics and Instruments,The Second Naval Hospital of Southern Theater Command,Sanya 572000,Hainan,China)
出处
《西部医学》
2020年第10期1538-1541,共4页
Medical Journal of West China
关键词
2型糖尿病
利拉鲁肽
NLRP3炎症小体
胰岛细胞功能
Type 2 diabetic
Liraglutide
Nod-like receptor pyrin domain 3 inflammasome
Insulin function
