摘要
目的探讨盐酸美金刚治疗帕金森痴呆的临床疗效。方法选取高安市人民医院2017年5月—2019年8月收治的帕金森痴呆患者56例,随机分为多巴丝组与美金刚组,各28例。多巴丝组予以多巴丝肼治疗,美金刚组予以盐酸美金刚治疗。比较2组治疗前后简易智力状态检查量表(MMSE)评分、蒙特利认知量表(MoCA)评分、神经精神症状问卷(NPI)评分及日常生活能力量表(ADL)评分,并观察2组不良反应发生情况。结果治疗前2组MMSE评分与MoCA评分比较,差异无统计学意义(P>0.05);治疗后美金刚组MMSE、MoCA评分高于多巴丝组(P<0.05)。治疗前2组NPI、ADL评分比较,差异无统计学意义(P>0.05);治疗后美金刚组NPI、ADL评分低于多巴丝组(P<0.05)。美金刚组不良反应发生率低于多巴丝组(P<0.05)。结论盐酸美金刚治疗帕金森痴呆的临床疗效确切,可有效促进患者脑神经功能恢复,改善痴呆症状,提高认知能力及生活自理能力,且安全性较高。
Objective To discuss the clinical effect of memantine hydrochloride on parkinson’s dementia. Methods A total of 56 cases of patients with parkinson’s dementia were selected from May 2017 to August 2019 in Gaoan People’s Hospital,which were randomly divided into dopa group and memantine group,with 28 cases in each group.The dopa group was treated with dobasine hydrazine,memantine group was treated with memantine hydrochloride.MMSE score,MoCA score,NPI score and ADL score before and after treatment were compared between the two groups,and the incidence of adverse reactions were observed.Results Before treatment,there was no significant difference in MMSE score,MoCA score,NPI score and ADL score between the two groups(P>0.05);after treatment,the memantine group of MMSE and MoCA scores were higher than dopa group,while NPI and ADL scores were lower than dopa group(P<0.05).The incidence rate of adverse reactions in memantine group was lower than dopa group(P<0.05).Conclusion Memantine hydrochloride has an exact clinical effect for parkinson’s dementia,which can effectively promote the recovery of brain nerve function, improve dementia symptoms, and improve cognitive ability and self-care ability,and with high safety.
作者
朱善军
敖艳丽
ZHU Shan-jun;AO Yan-li(Department of Neurology,Gaoan People’s Hospital,Gaoan 330800,China)
出处
《临床合理用药杂志》
2020年第24期33-35,共3页
Chinese Journal of Clinical Rational Drug Use
关键词
帕金森痴呆
盐酸美金刚
治疗结果
认知功能
Parkinson’s dementia
Memantine hydrochloride
Treatment outcome
Cognitive function
