摘要
目的观察双歧杆菌对质子泵抑制剂(PPIs)药物致老年胃食管反流病(GER)患者肠道菌群紊乱的纠正效果。方法选取2018年1月—2019年12月收治的长期服用PPIs药物的老年GER患者76例,采用随机数字表法分为观察组及对照组,各38例。另选择同期于该院进行健康体检、无GER且未服用PPIs药物的志愿者40例为健康对照组。对照组继续维持原有的PPIs药物治疗,观察组联合口服双歧杆菌活菌胶囊。比较3组研究对象纳入研究时以及观察组和对照组患者治疗1个月的肠道菌群数量、营养状况指标变化、血清肠黏膜屏障标志物水平,并记录治疗期间相关肠道并发症发生率。结果治疗前,观察组和对照组患者双歧杆菌、乳酸菌数量显著低于健康对照组(P<0.05),葡萄球菌、大肠埃希菌数量显著高于健康对照组(P<0.05);治疗后,对照组各肠道菌群数量均未发生显著变化(P>0.05),观察组双歧杆菌、乳酸菌数量显著提高(P<0.05),葡萄球菌、大肠埃希菌数量降低(P<0.05);治疗后,对照组各营养状况指标均未发生显著变化(P>0.05),观察组Hb、ALB水平显著提高(P<0.05);治疗后,对照组肠黏膜屏障标志物水平均未发生显著变化(P>0.05),观察组D-乳酸、DAO、PCT水平均显著降低(P<0.05);观察组并发症发生率显著低于对照组(P<0.05)。结论口服双歧杆菌活菌胶囊可有效纠正长期使用PPIs药物致老年GER患者肠道菌群紊乱,改善机体营养代谢状况及肠黏膜屏障功能,提高患者营养水平,促进胃肠道黏膜屏障修复,减少相关并发症的发生。
Objective To observe the effects of bifidobacterium in correcting intestinal flora disturbance in elderly patients with gastroesophageal reflux disease(GERD)caused by proton pump inhibitors(PPIs).Methods 76 elderly patients with GERD who took PPIs for a long time in the hospital between January 2018 and December 2019 were divided into observation group and control group by the random number method,38 cases in each group.Meanwhile,40 healthy volunteers who completed physical examination in the hospital during the same period were selected as the healthy control group.The control group were given original treatment with PPIs,and the observation group were additionally treated with oral bifidobacterium capsules.The quantity of intestinal flora,changes in nutrition status indexes,levels of serum intestinal mucosal barrier markers in the 3 groups at inclusion,the above indexes in the observation group and the control group after 1 month of treatment were compared.The incidence rate of related intestinal complications during treatment was recorded.Results Before treatment,the quantities of bifidobacteria and lactic acid bacteria in the observation group and the control group were significantly lower than those in the healthy control group(P<0.05),while the quantities of staphylococcus and Escherichia coli were significantly higher than the healthy control group(P<0.05).After treatment,there were no significant changes in the quantity of intestinal flora in the control group(P>0.05).In the observation group,the quantities of bifidobacteria and lactic acid bacteria were increased significantly(P<0.05),and the quantities of staphylococcus and Escherichia coli were decreased(P<0.05).After treatment,there were no significant changes in nutritional status indexes in the control group(P>0.05).In the observation group,Hb and ALB levels were increased significantly(P<0.05).After treatment,there were no significant changes in levels of intestinal mucosal barrier markers in the control group(P>0.05).The D-lactate,DAO and PCT leve
作者
黄敬敬
张辛铜
HUANG Jing-jing;ZHANG Xin-tong(Department of Gastroenterology,No.970 Hospital of PLA,Weihai,Shandong 264200,China)
出处
《实用医药杂志》
2020年第10期887-892,共6页
Practical Journal of Medicine & Pharmacy
关键词
双歧杆菌
质子泵抑制剂
胃食管反流
肠道菌群紊乱
Bifidobacterium
Proton pump inhibitor
Gastroesophageal reflux
Intestinal flora disturbance
