摘要
神经性疼痛是由神经元病变引起的疼痛状态,目前缺乏合适治疗方法。神经元异常放电、离子通道改变及多种蛋白质表达均与神经性疼痛相关。光遗传学作为一个新兴领域,结合了光和基因的力量,利用光介导的蛋白质—蛋白质相互作用以精确调控神经元细胞、离子通道和蛋白质等。因此,光遗传学在未来的神经性疼痛治疗中极具前景。文章就光遗传学在神经性疼痛中的应用进行综述。
Neuropathic pain is a state of pain caused by neuronal disease,and there is currently a lack of appropriate treatment methods.Abnormal discharge of neurons,changes in ion channels and expression of a variety of proteins are all related to neuropathic pain.As an emerging field,optogenetics combines the power of light and genes,and uses light-mediated protein-protein interactions to precisely regulate neuronal cells,ion channels,and proteins.Therefore,optogenetics is very promising in the future treatment of neuropathic pain.This article reviews the application of optogenetics in neuropathic pain.
作者
王倩文(综述)
王龙
王晞(审校)
Wang Qianwen;Wang Long;Wang Xi(Department of Anesthesiology,Renmin Hospital of Wuhan University,Hubei Province,Wuhan 430060,China)
出处
《疑难病杂志》
CAS
2020年第10期1072-1076,共5页
Chinese Journal of Difficult and Complicated Cases
基金
国家自然科学基金资助项目(81772044)。
关键词
神经性疼痛
光遗传学
治疗
综述
Neuropathic pain
Optogenetics
Therapy
Review
