摘要
目的研究高龄老年患者血浆D-二聚体(DD)在急性血栓形成时的变化及临床意义。方法收集2015年1月至2019年12月于解放军总医院第七医学中心干部病房住院的高龄老年患者,入选急性血栓性疾病包括急性下肢静脉栓塞、急性脑梗死、急性心肌梗死、急性肺栓塞患者150例作为血栓组,未合并血栓形成的同期住院患者172例作为对照组,比较两组患者及不同血栓疾病患者DD及凝血相关指标[凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血酶时间(APTT)与纤维蛋白原(Fib)]的变化。结果血栓组患者血浆DD水平、Fib明显高于对照组(P<0.05)。血栓组患者PT、TT、APTT水平明显低于对照组(P<0.05)。急性肺栓塞、急性下肢深静脉血栓疾病患者血浆DD、Fib水平明显高于急性心肌梗死和急性脑梗死患者(P<0.05),而急性下肢深静脉血栓和急性肺栓塞患者间无明显统计学差异(P>0.05)。急性心肌梗死和急性脑梗死患者间无明显统计学差异(P>0.05)。急性肺栓塞、急性下肢深静脉血栓患者PT、TT、APTT水平明显低于急性心肌梗死和急性脑梗死患者(P<0.05),而急性下肢深静脉血栓和急性肺栓塞患者间无明显统计学差异(P>0.05),急性心肌梗死和急性脑梗死患者间无明显统计学差异(P>0.05)。结论血浆DD水平与急性血栓疾病形成密切相关,高龄老年患者入院常规检测DD,可便于及时发现高凝状态及血栓形成疾病,及时采取抗凝治疗,以减低急性栓塞事件发生。
Objective To study the changes and clinical significance of plasma D-Dimer(DD)in elderly patients with acute thrombosis.Method From January 2015 to December 2019,the elderly inpatients in the cadre ward of the seventh medical center of the PLA General Hospital were collected.150 patients with acute thrombotic diseases,including acute lower extremity vein embolism,acute cerebral infarction,acute myocardial infarction and acute pulmonary embolism,were selected as the thrombus group,and 172 patients in the same period without thrombus formation as the control group.The patients in the two groups and their differences were compared The changes of DD and coagulation related indexes(prothrombin time(PT),thrombin time(TT),activated partial thrombin time(APTT)and fibrinogen(FIB))in patients with thrombotic diseases.Results The levels of plasma DD and Fib in thrombus group were significantly higher than those in control group(P<0.05).The levels of PT,TT and APTT in thrombus group were significantly lower than those in control group(P<0.05).The levels of plasma DD and Fib in patients with acute pulmonary embolism and acute lower extremity deep vein thrombosis were significantly higher than those in patients with acute myocardial infarction and acute cerebral infarction(P<0.05),but there was no significant difference between patients with acute lower extremity deep vein thrombosis and acute pulmonary embolism(P>0.05).There was no significant difference between acute myocardial infarction and acute cerebral infarction(P>0.05).The levels of PT,TT and APTT in patients with acute pulmonary embolism and acute deep vein thrombosis of lower extremities were significantly lower than those in patients with acute myocardial infarction and acute cerebral infarction(P<0.05),but there was no significant difference between patients with acute deep vein thrombosis of lower extremities and acute pulmonary embolism(P>0.05),and there was no significant difference between patients with acute myocardial infarction and acute cerebral infarction
作者
田国祥
武云涛
姚璐
张薇
Tian Guoxiang;Wu Yuntao;Yao Lu;Zhang Wei(Department of Geriatric Medicine,Seventh Medical Center of Chinese PLA General Hospital,Beijing 100700,China;不详)
出处
《中国循证心血管医学杂志》
2020年第9期1055-1058,共4页
Chinese Journal of Evidence-Based Cardiovascular Medicine
基金
军队保健专项课题(15BJZ03)
全军十二五科研面上课题(CWS11J216)。
关键词
高龄
D-二聚体
血栓性疾病
急性
Senile patients
D-dimer
Thrombotic diseases
Acute
