摘要
目的用Meta分析法综合评价CT引导下经皮肺穿刺活检在鉴别孤立性肺结节(Solitary Pulmonary Nodules,SPNs)良恶性的诊断价值。方法系统搜索Medline、PubMed、VIP、中国期刊全文数据库(CNKI)和万方医学网等数据库,检索时间截至2019年3月,检索使用CT引导下经皮肺穿刺活检诊断SPNs的相关中外文献,按照Cochrane协作网推荐的诊断试验纳入标准筛选文献,提取纳入研究文献的特征信息。文献评价采用诊断研究评价工具QUADAS,Meta分析采用Stata15.1软件进行。结果共纳入12篇研究文献,共计1053例病人。汇总计算特异度、灵敏度、阳性似然比、阴性似然比和诊断比值比,绘制汇总受试者工作特征(SROC)曲线并计算曲线下面积(AUC),以及95%CI,分别为0.99(0.85~1.00),0.95(0.90~0.98),91.5(5.70~1460.50),0.05(0.02~0.10),1921(117.00~31666.00)、0.99(0.98~1.00).结论CT引导下经皮肺穿刺活检应用于肺部SPNs的诊断,具有较高的特异度、灵敏度以及准确率,是肺部SPNs的一项重要诊断方法,具有较高诊断效能。
Objective To comprehensive evaluate the diagnosis value of CT-guided percutaneous lung biopsy in the identification of solitary pulmonary nodules(SPNs)of benign and malignant with a Meta-analysis.MethodsRelevant English and Chinese literatureson CT-guided percutaneous lung biopsy to diagnose SPNs were searched in the Medline,PubMed,VIP,CNKI and WANFANG databases,with retrieval time until March 2019.According to the inclusion criteria recommended by the Cochrane Methods Group on Screening and Diagnostic Tests,,the literatures were screened and the characteristic information of the included researches was extracted.The literature evaluation was performed using the diagnostic research evaluation tool QUADAS,and Meta-analysis was performed using Stata 15.1.ResultsA total of 12 studies were included,with a total of 1053 patients.The specificity,sensitivity,positive likelihood ratio,negative likelihood ratio and diagnostic ratio were calculated,and the SROC curves were drawn and the area under the curve and the 95%CI were calculated as0.99(0.85~1.00),0.95(0.90~0.98),91.5(5.7~1460.5),0.05(0.02~0.10),1921(117~31666.00)、0.99(0.98~1.00),respectively.ConclusionCT-guided percutaneous lung biopsy has been applied to the diagnosis of pulmonary SPNs with high specificity,sensitivity and accuracy,and is an important diagnostic method of pulmonary SPNs with high diagnostic efficiency.
作者
赵瑞婧
王丽娜
李娜苗
张莹莹
范亚莉
鱼军
李亚
李建英
ZHAO Ruijing;WANG Lina;LI Namiao;ZHANG Yingying;FAN Yali;YU Jun;LI Ya;LI Jianying(Department of Respiration,Xi’an Central Hospital,Xi’an,Shaanxi 710003,China;Department of Emergency,Xi’an Central Hospital,Xi’an,Shaanxi 710003,China;Medical College of Yan’an University,Yan’an,Shaanxi 716000,China;Department of Respiratory and Critical Care Medwine,The Hospital of Gaoling District,Xi’an,Shaanxi 710200,China)
出处
《安徽医药》
CAS
2020年第10期1909-1913,共5页
Anhui Medical and Pharmaceutical Journal
基金
陕西省重点研发计划项目(2019SF-020)。
