摘要
目的观察疏肝调神针刺法联合丁螺环酮对复发性抑郁症患者认知功能、社会功能及血清S100β蛋白的影响。方法选择116例复发性抑郁症患者作为研究对象,根据随机数字表随机分为对照组(58例)和针刺组(58例)。对照组给予丁螺环酮口服治疗,针刺组给予疏肝调神针刺法联合丁螺环酮治疗,比较两组认知功能、社会功能及血清S100β蛋白水平,并评价临床效果。结果针刺组总有效率为89.7%,对照组为74.1%,两组比较差异有统计学意义(P<0.05);两组治疗前后汉密尔顿抑郁量表(HAMD-17)评分、重复性成套神经心理状态测验(RBANS)评分、席汉残疾量表(Sheehan disability scale,SDS)评分、副反应量表系统(TESS)评分、血清S100β蛋白水平、中医证候积分比较差异均有统计学意义(P<0.05),其中针刺组治疗2周、4周、8周后HAMD-17评分和血清S100β蛋白水平显著低于对照组(P<0.05),针刺组治疗后SDS评分(社会生活、工作学习、家庭责任)和中医证候积分低于对照组(P<0.05),RBANS评分(语言、空间结构、注意力、即刻记忆、延迟记忆)显著高于对照组(P<0.05),治疗2周、8周两组TESS评分比较差异无统计学意义(P>0.05)。结论疏肝调神针刺法联合丁螺环酮治疗复发性抑郁症可显著改善抑郁症状,提高患者认知功能和社会功能,降低血清S100β蛋白水平,安全有效,不良反应小。
Objective To observe the effects of Shu Gan Tiao Shen(liver-soothing and mind-regulating)needling method combined with Buspirone on cognitive function,social function and serum S100βprotein in patients with recurrent depression.Method A total of 116 patients with recurrent depression were recruited as subjects and divided into a control group(58 cases)and an acupuncture group(58 cases)by the random number table method.The control group was given oral administration of Buspirone,while the acupuncture group was given Shu Gan Tiao Shen needling treatment plus Buspirone.The cognitive function,social function and serum S100βprotein in the two groups were compared.The clinical efficacy was also evaluated.Result The total effective rate was 89.7%in the acupuncture group versus 74.1%in the control group,and the between-group difference was statistically significant(P<0.05);the scores of Hamilton Depression Scale(HAMD)-17,Repeatable Battery for the Assessment of Neuropsychological Status(RBANS),Sheehan Disability Scale(SDS)and Treatment Emergent Symptom Scale(TESS),serum S100βprotein,and traditional Chinese medicine(TCM)symptom score changed significantly after treatment in the two groups(P<0.05).Among which,the HAMD-17 score and serum S100βprotein level were significantly lower in the acupuncture group than in the control group at treatment weeks 2,4 and 8(P<0.05);the SDS(social life,work and study,family responsibility)and TCM symptom scores were lower in the acupuncture group than in the control group after treatment(P<0.05),and the RBANS scores(language,spatial structure,attention,real-time memory and delayed memory)was higher in the acupuncture group than in the control group(P<0.05).The between-group differences in the TESS score were statistically insignificant at treatment weeks 2 and 8(P>0.05).Conclusion Shu Gan Tiao Shen needling method plus Buspirone can significantly improve the depression symptoms,cognitive function and social function,and down-regulate the serum S100βprotein in patients with recurrent d
作者
唐颖
张素娟
赵蕊
崔璐莎
刘欣
王亚楠
TANG Ying;ZHANG Su-juan;ZHAO Rui;CUI Lu-sha;LIU Xin;WANG Ya-nan(Kailuan Mental Health Center,Tangshan 063001,China)
出处
《上海针灸杂志》
2020年第10期1259-1264,共6页
Shanghai Journal of Acupuncture and Moxibustion
基金
河北省医学科学研究课题(20191324)。
