摘要
目的探讨高血压脑出血老年患者血管性痴呆发病的因素分析及血清脂蛋白相关磷酸酶A2(Lp-PLA2)的相关性研究。方法回顾性分析2017年6月—2019年7月商丘市中心医院收治的168例高血压脑出血老年患者的临床资料,依据患者认知功能障碍程度随机分为A组(血管性痴呆组,n=79)、B组(非痴呆性认知功能障碍组,n=49)、C组(认知正常组,n=40)。比较3组患者各实验室相关指标和认知功能,单因素和Logistic多因素分析高血压脑出血老年患者发生血管性痴呆的相关因素。结果A组患者的血清游离三碘甲状腺原氨酸(FT3)、总甲状腺素(TT4)、游离甲状腺素(FT4)水平低于B组和C组,血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL)、Lp-PLA2水平高于B组和C组,B组患者的血清FT3、TT4、FT4水平低于C组,血清TC、TG、LDL、Lp-PLA2水平高于C组,差异具有统计学意义(P<0.05)。A组患者的短时记忆、空间视觉、注意力计算力、瞬时记忆、语言能力、定向力和MMSE总分均低于B组和C组,B组患者各项能力均低于C组,差异具有统计学意义(P<0.05)。单因素分析结果显示,年龄、饮酒、文化程度、病灶大小、血清Hcy、FT3、TT4、FT4、TC、TG、LDL、Lp-PLA2水平与高血压脑出血老年患者发生血管性痴呆存在相关性(P<0.05)。Logistic多因素分析结果显示,高龄、小学及以下文化、血清高Hcy和高Lp-PLA2水平是高血压脑出血老年患者发生血管性痴呆的危险因素(P<0.05)。结论高血压脑出血发生血管性痴呆的老年患者血清FT3、TT4、FT4水平降低,血清TC、TG、LDL、Lp-PLA2水平升高,认知功能降低,高龄、小学及以下文化、血清高Hcy和高Lp-PLA2水平是发病的危险因素,临床中应加强监控。
Objective To investigate the risk factors of vascular dementia in elderly patients with hypertensive cerebral hemorrhage and its correlation with serum lipoprotein-associated phosphatase A2(LP-PLA2).Methods The clinical data of 168 elderly patients with hypertensive cerebral hemorrhage admitted to our hospital from June 2017 to July 2019 were retrospectively analyzed.According to the degree of cognitive impairment,the patients were randomly divided into Group A(vascular dementia group,n=79),group B(non-dementia cognitive impairment group,n=49),and group C(normal cognitive impairment group,n=40).The laboratory indicators and cognitive function of patients in the three groups were compared,and the factors related to vascular dementia in elderly patients with hypertensive cerebral hemorrhage were analyzed by univariate and Logistic multivariate analyses.Results The results of A group of patients with serum free thyroid original three iodine glycine(FT3),total thyroxine(TT4)and free thyroxine(FT4)levels lower than that of group B and group C,serum total cholesterol(TC),three acyl glycerin(TG),low density lipoprotein cholesterol(LDL),Lp-PLA2 level higher than that of group B and group C,group B patients serum FT3,TT4,FT4 level lower than that of group C,serum TC,TG,LDL,Lp-PLA2 level higher than that of group C,statistically significant difference(P<0.05).The short-term memory,visuospatial perception,attentional computing power,instantaneous memory,language ability,directional ability and MMSE total score of group A were all lower than those of group B and Group C,and the differences were statistically significant(P<0.05).Univariate analysis showed that age,alcohol consumption,degree of education,lesion size,serum Hcy,FT3,TT4,FT4,TC,TG,LDL,LP-PLA2 levels were correlated with vascular dementia in elderly patients with hypertensive cerebral hemorrhage(P<0.05).The results of Logistic multivariate analysis showed that the risk factors of vascular dementia in elderly patients with hypertensive intracerebral hemorrhage were
作者
吴海燕
WU Hai-yan(Shangqiu Central Hospital,Henan Shangqiu 476000,China)
出处
《医药论坛杂志》
2020年第9期66-69,共4页
Journal of Medical Forum
关键词
高血压
脑出血
老年
脂蛋白相关磷酸酶A2
血管性痴呆
Hypertension
Cerebral hemorrhage
Old age
Lipoprotein-associated phosphatase A2
Vascular dementia
