摘要
慢性鼻窦炎(CRS)是耳鼻咽喉头颈外科的常见病,一项多中心流行病学调查显示我国CRS的总患病率为8.0%(4.8%~9.7%)[1],成为影响人们健康的常见慢性疾病之一。CRS具有显著的异质性,临床根据鼻内镜检查结果分为慢性鼻窦炎不伴鼻息肉(chronic rhinosinusitis without nasal polyps,CRSsNP)和慢性鼻窦炎伴鼻息肉(chronic rhinosinusitis with nasal polyps,CRSwNP)2种表型。
Chronic rhinosinusitis(CRS)is a heterogeneous inflammatory disease with an as-yet-undefined etiology.In contrast to the phenotypic classification of chronic rhinosinusitis,endotype classification is based on its underlying pathophysiological mechanisms.Endotypes of CRS can provide information on the risk of disease progression,recurrence and comorbidities,as well as identify appropriate therapeutic targets to further guide the precise treatment of CRS.This article classifies the endotypes of CRS based on cytokines,cell composition,IgE and CysLT,and outlines the clinical application of several targeted therapeutic biologics.
作者
孙立薇
朱冬冬
孟粹达
SUN Liwei;ZHU Dongdong;MENG Cuida
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
北大核心
2020年第8期765-768,共4页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
基金
国家自然科学基金(No:81570897,81870701)
吉林省卫生科研人才专项项目(No:2019scz004)
吉林省直卫生专项项目(No:2018scz042)。
关键词
鼻窦炎
免疫应答
诊断
治疗
sinusitis
immune response
diagnosis
treatment
